Exploring sustainable analytical techniques using G score and future innovations in green analytical chemistry

Kannaiah, Kanaka Parvathi; Chanduluru, Hemanth Kumar

doi:10.1016/j.jclepro.2023.139297

Cited by 6 publications

(1 citation statement)

References 115 publications

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“…The ecological consequence of the analytical techniques was assessed using four main criteria: high energy consumption, high waste production, excessive chemical use and associated risks, and large chemical usage 23 , 24 . The cost-effectiveness and environmental friendliness of the proposed method were assessed using two analytical techniques as follows:…”

Section: Resultsmentioning

confidence: 99%

Greenness and whiteness assessment of a sustainable voltammetric method for difluprednate estimation in the presence of its alkaline degradation product

El-Hadi,

Eissa,

Eltanany

et al. 2024

Sci Rep

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Nowadays, scientists are currently attempting to lessen the harmful effects of chemicals on the environment. Stability testing identifies how a drug’s quality changes over time. The current work suggests a first and sustainable differential pulse voltammetry technique for quantifying difluprednate (DIF) as an anti-inflammatory agent in the presence of its alkaline degradation product (DEG). The optimum conditions for the developed method were investigated with a glassy carbon electrode and a scan rate of 100 mV s−1. The linearity range was 2.0 × 10−7–1.0 × 10−6 M for DIF. DIF was found to undergo alkaline degradation, when refluxed for 8 h using 2.0 M NaOH, and DEG was successfully characterized utilizing IR and MS/MS. The intended approach demonstrated the selectivity for DIF identification in pure, pharmaceutical, and degradation forms. The student’s t-test and F value were used to compare the suggested and reported approaches statistically. The results were validated according to ICH requirements. The greenness of the studied approach was evaluated using the Green Analytical Procedure Index and the Analytical Greenness metric. Additionally, the whiteness features of the proposed approach were examined with the recently released red, green, and blue 12 model, and the recommended strategy performed better than the reported approaches in greenness and whiteness.

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Section: Resultsmentioning

confidence: 99%

Greenness and whiteness assessment of a sustainable voltammetric method for difluprednate estimation in the presence of its alkaline degradation product

El-Hadi,

Eissa,

Eltanany

et al. 2024

Sci Rep

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One‐pot derivatization spectrofluorimetric method for detection of aspartame in sweetener commercial tablets and soft drinks: Greenness assessments of the methodology

AlSalem,

Alharbi,

Binkadem

et al. 2024

Luminescence

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Aspartame is an artificial sweetener used in drinks and many foods. International Agency for Research on Cancer classified aspartame as possibly carcinogenic to humans (IARC Group 2B). In this study, a sensitive and selective spectrofluorimetric method was developed to detect aspartame. The method is based on switching on the fluorescence activity of aspartame upon its condensation with O‐phthalaldehyde (Roth's reaction) in the presence of 2‐mercaptoethanol. The reaction product was detected fluorometrically at λem of 438 nm after λex of 340 nm. All reaction conditions required to yield the optimal fluorescence intensity were observed and investigated. Furthermore, the approach was validated according to ICH guidelines. Upon plotting the concentrations of aspartame against their associated fluorescence intensity values, the relationship between the two variables was linear within the range of 0.5–3.0 μg/mL. Furthermore, the method was employed to analyze the quantity of aspartame in commercial packages and soft drinks with an acceptable level of recovery. In addition, the Green Solvents Selecting Tool, Complementary Green Analytical Procedure Index, and the Analytical Greenness Metric tool were used to evaluate the sustainability and the greenness of the developed methodology.

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Propylene carbonate as an ecofriendly solvent: Stability studies of Ripretinib in RPHPLC and sustainable evaluation using advanced tools

Fayaz,

Chanduluru,

Obaydo

et al. 2024

Sustainable Chemistry and Pharmacy

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Exploring sustainable analytical techniques using G score and future innovations in green analytical chemistry

Cited by 6 publications

References 115 publications

Greenness and whiteness assessment of a sustainable voltammetric method for difluprednate estimation in the presence of its alkaline degradation product

Greenness and whiteness assessment of a sustainable voltammetric method for difluprednate estimation in the presence of its alkaline degradation product

One‐pot derivatization spectrofluorimetric method for detection of aspartame in sweetener commercial tablets and soft drinks: Greenness assessments of the methodology

Propylene carbonate as an ecofriendly solvent: Stability studies of Ripretinib in RPHPLC and sustainable evaluation using advanced tools

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