Exploring somatosensory innervation of the human lip: A focus on the vermilion

Martín-Cruces, José; Martín-Biedma, Benjamín; García-Mesa, Yolanda; Cuendias, Patricia; Gaite, Juan J.; García-Suárez, Olivia; Cobo, Juan L.; Vega, José A.

doi:10.1016/j.aanat.2023.152159

Cited by 3 publications

(3 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The present study was designed to investigate the presence of PIEZO1 and PIEZO2 in Krause's corpuscles from human glans clitoridis. Our findings on PIEZO2 expression in the axon are in complete agreement with previous studies in human CEOCs in different anatomical locations [12,18,20,28] but also in mice ones [10][11][12]14,19,29], including clitoral Krause's corpuscles [9,10]. Furthermore, we observed here that about 30% of these corpuscles display PIEZO2 immunoreactivity in terminal glial cells.…”

Section: Discussionsupporting

confidence: 92%

“…Recently, PIEZO2 has been detected in mouse clitoral Krause’s corpuscles [ 10 ], whose function is needed for triggering touch-evoked erection reflex and successful mating in both male and female mice. On the other hand, humans with complete loss of PIEZO2 function have genital hyposensitivity and experience no direct pleasure from gentle touch or vibration [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles

Cuendias,

Vega,

García-Suárez

et al. 2024

IJMS

View full text Add to dashboard Cite

Krause’s corpuscles are typical of cutaneous mucous epithelia, like the lip vermillion or the glans clitoridis, and are associated with rapidly adapting low-threshold mechanoreceptors involved in gentle touch or vibration. PIEZO1 and PIEZO2 are transmembrane mechano-gated proteins that form a part of the cationic ion channels required for mechanosensitivity in mammalian cells. They are involved in somatosensitivity, especially in the different qualities of touch, but also in pain and proprioception. In the present study, immunohistochemistry and immunofluorescence were used to analyze the occurrence and cellular location of PIEZO1 and PIEZO2 in human clitoral Krause’s corpuscles. Both PIEZO1 and PIEZO2 were detected in Krause’s corpuscles in both the axon and the terminal glial cells. The presence of PIEZOs in the terminal glial cells of Kraus’s corpuscles is reported here for the first time. Based on the distribution of PIEZO1 and PIEZO2, it may be assumed they could be involved in mechanical stimuli, sexual behavior, and sexual pleasure.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Axonal and Glial PIEZO1 and PIEZO2 Immunoreactivity in Human Clitoral Krause’s Corpuscles

Cuendias,

Vega,

García-Suárez

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

“…I would be surprised if the pertinent activities in the speech musculature fell below the threshold of detection by human interoception. The tongue and lips are densely packed with assorted kinds of receptors to detect such things as taste, temperature, pressure, movement, and stretching (for the lips, see Martín-Cruces et al, 2023 ). They are even more sensitive than the fingertips.…”

Section: Supporting Data and How Bet Can Be Empirically Testedmentioning

confidence: 99%

Inner speech and the body error theory

Endicott

2024

Front. Psychol.

View full text Add to dashboard Cite

Inner speech is commonly understood as the conscious experience of a voice within the mind. One recurrent theme in the scientific literature is that the phenomenon involves a representation of overt speech, for example, a representation of phonetic properties that result from a copy of speech instructions that were ultimately suppressed. I propose a larger picture that involves some embodied objects and their misperception. I call it “the Body Error Theory,” or BET for short. BET is a form of illusionism, but the particular version I favor is a cross-modal illusion. Newly described here, my hypothesis is that the experience of inner speech arises from a mix of interoception and audition. Specifically, there is the detection of slight but well-confirmed activities in the speech musculature that occur during inner speech, which helps to transform representations of normal but quiet nonverbal sounds that inevitably occur during inner speech, from breathing to background noise, into a mistaken perception of inner speech. Simply put, activities in the speech musculature mix with sounds to create the appearance of speech sounds, which thus explains the “voice within the mind.” I also show how BET’s cross-modal system fits with standard information processing accounts for speech monitoring and how it accommodates the central insights of leading theories of inner speech. In addition, I show how BET is supported by data from experience-sampling surveys and how it can be empirically tested against its rivals.

show abstract