Exploring silver nanoparticles for cancer therapy and diagnosis

Miranda, Renata Rank; Sampaio, Isabella; Zucolotto, Valtencir

doi:10.1016/j.colsurfb.2021.112254

Cited by 74 publications

(52 citation statements)

References 119 publications

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“…Silver nanoparticles (AgNPs), just like gold nanoparticles, also possess low toxicity, high thermal stability, and low volatility, which makes them desirable for anticancer drugs. , Especially when these AgNPs are conjugated with biomolecules, they display desired pharmaceutical properties. Figure shows the anticancer properties of AgNPs .…”

Section: Inorganic Nddss In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

183

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Traditional treatment approaches for cancer involve intravenous chemotherapy or other forms of drug delivery. These therapeutic measures suffer from several limitations such as nonspecific targeting, poor biodistribution, and buildup of drug resistances. However, significant technological advancements have been made in terms of superior modes of drug delivery over the last few decades. Technical capability in analyzing the molecular mechanisms of tumor biology, nanotechnologyparticularly the development of biocompatible nanoparticles, surface modification techniques, microelectronics, and material scienceshas increased. As a result, a significant number of nanostructured carriers that can deliver drugs to specific cancerous sites with high efficiency have been developed. This particular maneuver that enables the introduction of a therapeutic nanostructured substance in the body by controlling the rate, time, and place is defined as the nanostructured drug delivery system (NDDS). Because of their versatility and ability to incorporate features such as specific targeting, water solubility, stability, biocompatibility, degradability, and ability to reverse drug resistance, they have attracted the interest of the scientific community, in general, and nanotechnologists as well as biomedical scientists. To keep pace with the rapid advancement of nanotechnology, specific technical aspects of the recent NDDSs and their prospects need to be reported coherently. To address these ongoing issues, this review article provides an overview of different NDDSs such as lipids, polymers, and inorganic nanoparticles. In addition, this review also reports the challenges of current NDDSs and points out the prospective research directions of these nanocarriers. From our focused review, we conclude that still now the most advanced and potent field of application for NDDSs is lipid-based, while other significantly potential fields include polymer-based and inorganic NDDSs. However, despite the promises, challenges remain in practical implementations of such NDDSs in terms of dosage and stability, and caution should be exercised regarding biocompatibility of materials. Considering these aspects objectively, this review on NDDSs will be particularly of interest for small-to-large scale industrial researchers and academicians with expertise in drug delivery, cancer research, and nanotechnology.

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Section: Inorganic Nddss In Cancer Therapymentioning

confidence: 99%

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Khan

Hossain

et al. 2022

ACS Appl. Bio Mater.

183

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“…In addition, the structural characteristics of AgNPs (shape and size) influence the antioxidant activity [ 175 ].…”

Section: Resultsmentioning

confidence: 99%

Untargeted Metabolomic Approach of Curcuma longa to Neurodegenerative Phytocarrier System Based on Silver Nanoparticles

et al. 2022

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Curcuma is one of the most famous medicinal and tropical aromatic plants. Its health benefits have been appreciated and exploited in traditional Asian medicine since ancient times. Various studies have investigated its complex chemical composition and demonstrated the remarkable therapeutic properties of curcuma’s phytoconstituents. Oxidative stress is a decisive driving factor triggering numerous pathologies (neurodegenerative, psychiatric and cardiovascular diseases; diabetes; tumors, etc.). Numerous recent studies have focused on the use of natural compounds and nanomaterials as innovative molecular targeting agents as effective therapeutic strategies. In this study, we report, for the first time, the development of a simple target phytocarrier system that capitalizes on the bioactive properties of curcuma and AgNPs. The complete metabolic profile of curcuma was determined based on gas chromatography-mass spectrometry (GC-MS) and electrospray ionization quadrupole time-of-flight mass spectrometry (ESI-QTOF-MS). A total of 80 metabolites were identified under mass spectra (MS)-positive mode from 10 secondary metabolite categories: terpenoids, amino acids, diarylheptanoids, flavonoids, phenolic acids, steroids, fatty acids, coumarins, alkaloids and miscellaneous. In addition, the biological activity of each class of metabolites was discussed. A comprehensive characterization (FT-IR, UV-Vis, DLS, SEM, TEM, EDS, zeta potential and XRD) was performed to study the morphostructural properties of this new phytocarrier system. Antioxidant activity of the new phytocarrier system was evaluated using a combination of in vitro methods (total phenolic assay, 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay and cyclic voltammetric method (Trolox equivalent antioxidant capacity (TEAC) electrochemical assay)). Antioxidants assays showed that the phytocarrier system exhibits superior antioxidant properties to those of its components, i.e., curcuma or citrate-coated-AgNPs. These data confirm the potential to enhance relevant theoretical knowledge in the area of innovative antioxidant agents, with potential application in neurodegenerative therapeutic strategies.

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“…Ag NPs can also act by regulating signaling pathways, inducing early apoptosis in the absence of the p53 tumor suppressor [6,40,43]. Moreover, NPs can release Ag + cations that capture electrons, increase intracellular oxidative stress, increase ROS production, reduce ATP levels of cancer cells, and decrease cell proliferation rates [6,44]. Ag + ions are reportedly released mainly in mitochondria and secondarily in the nuclei; there, they interact with DNA, resulting in its fragmentation and resulting in cell death [43,45].…”

Section: Silver Npsmentioning

confidence: 99%

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

et al. 2022

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Cancer continues to represent a global health concern, imposing an ongoing need to research for better treatment alternatives. In this context, nanomedicine seems to be the solution to existing problems, bringing unprecedented results in various biomedical applications, including cancer therapy, diagnosing, and imaging. As numerous studies have uncovered the advantageous properties of various nanoscale metals, this review aims to present metal-based nanoparticles that are most frequently employed for cancer applications. This paper follows the description of relevant nanoparticles made of metals, metal derivatives, hybrids, and alloys, further discussing in more detail their potential applications in cancer management, ranging from the delivery of chemotherapeutics, vaccines, and genes to ablative hyperthermia therapies and theranostic platforms.

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Exploring silver nanoparticles for cancer therapy and diagnosis

Cited by 74 publications

References 119 publications

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Recent Progress in Nanostructured Smart Drug Delivery Systems for Cancer Therapy: A Review

Untargeted Metabolomic Approach of Curcuma longa to Neurodegenerative Phytocarrier System Based on Silver Nanoparticles

Recent Developments in Metallic Nanomaterials for Cancer Therapy, Diagnosing and Imaging Applications

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