Exploring Potential of Aspergillus sclerotiorum: Secondary Metabolites and Biotechnological Relevance

Ibrahim, Sabrin R. M.; Abdallah, Hossam M.; Mohamed, Gamal A.; Deshmukh, Sunil K.

doi:10.1007/s11557-022-01856-3

Cited by 4 publications

(4 citation statements)

References 82 publications

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“…The ligninolytic enzymes Lac (laccase), LiP (lignin peroxidase), VP (versatile peroxidase), and Mnp (manganese peroxidase) play a major role in the breakdown of lignin [ 105 , 106 ] and are found among the extracellular enzymes in filamentous fungi. These enzymes play a significant role in bioremediation, as they neutralize or degrade contaminants in the environment [ 6 ]. They also have a wide range of uses in the paper, textile, cosmetic, food, chemical, agricultural, and energy industries.…”

Section: Industrial and Biotechnological Applicationsmentioning

confidence: 99%

“…Whole microorganism cells are effectively used as catalysts in the stereoselective biotransformation of a variety of chemical molecules. Also, many chemical reactions such as carbonyl ketone reduction, sulfide oxidation, secondary alcohol deracemization, and Baeyer–Villiger reactions were all catalyzed by enzymes from various microorganisms [ 6 ]. The whole cell of A. sydowii was investigated as a biocatalyst for various chemical reactions.…”

Section: Industrial and Biotechnological Applicationsmentioning

confidence: 99%

“…Additionally, fungal enzymes have been utilized instead of chemical processes in various industries, including those of textiles, leather, paper, pulp, animal feed, baked goods, beer, wine, and juice, which greatly reduces negative environmental effects [ 5 ]. Genus Aspergillus (Moniliaceae) is one of the most valuable fungal genera of commercial, biotechnological, and medicinal importance [ 6 , 7 , 8 ]. It comprises 400 species and attracts remarkable interest as a wealthy pool of structurally varied metabolites, including terpenoids, alkaloids, peptides, xanthones, and polyketides [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

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Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

Ibrahim,

Mohamed,

Alsaadi

et al. 2023

Marine Drugs

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Marine-derived fungi are renowned as a source of astonishingly significant and synthetically appealing metabolites that are proven as new lead chemicals for chemical, pharmaceutical, and agricultural fields. Aspergillus sydowii is a saprotrophic, ubiquitous, and halophilic fungus that is commonly found in different marine ecosystems. This fungus can cause aspergillosis in sea fan corals leading to sea fan mortality with subsequent changes in coral community structure. Interestingly, A. sydowi is a prolific source of distinct and structurally varied metabolites such as alkaloids, xanthones, terpenes, anthraquinones, sterols, diphenyl ethers, pyrones, cyclopentenones, and polyketides with a range of bioactivities. A. sydowii has capacity to produce various enzymes with marked industrial and biotechnological potential, including α-amylases, lipases, xylanases, cellulases, keratinases, and tannases. Also, this fungus has the capacity for bioremediation as well as the biocatalysis of various chemical reactions. The current work aimed at focusing on the bright side of this fungus. In this review, published studies on isolated metabolites from A. sydowii, including their structures, biological functions, and biosynthesis, as well as the biotechnological and industrial significance of this fungus, were highlighted. More than 245 compounds were described in the current review with 134 references published within the period from 1975 to June 2023.

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Section: Industrial and Biotechnological Applicationsmentioning

confidence: 99%

Section: Industrial and Biotechnological Applicationsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

Ibrahim,

Mohamed,

Alsaadi

et al. 2023

Marine Drugs

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“…Ecteinascidin-743 (ET743) is a novel anti-tumor drug on the market [8]. Aspergillus sclerotiorum have potential to biosynthesize alkaloids, though alkaloids are the most bioactive metabolites that possess marked antimicrobial and cytotoxic activities [9]. Sclerotiamides C and F, which are isolated from the A. sclerotiorum LZDX-33-4, a fungus derived from a gorgonian coral (LZDX-33), showed a significant inhibitory effect against a panel of tumor cell lines with IC 50 values ranging from 1.6 to 7.9 µM [10].…”

Section: Introductionmentioning

confidence: 99%

Sclerotioloids A–C: Three New Alkaloids from the Marine-Derived Fungus Aspergillus sclerotiorum ST0501

et al. 2023

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Alkaloids, as one of the largest classes of natural products with diverse structures, are an important source of innovative medicines. Filamentous fungi, especially those derived from the marine environment, are one of the major producers of alkaloids. In this study, three new alkaloids, sclerotioloids A−C (1−3), along with six known analogs (4−9), were obtained under the guidance of the MS/MS-based molecular networking from the marine-derived fungus, Aspergillus sclerotiorum ST0501, collected from the South China Sea. Their chemical structures were elucidated by comprehensive analysis of the spectroscopic data, including 1D and 2D NMR and HRESIMS. Additionally, the configuration of compound 2 was unambiguously determined by X-ray single crystal diffraction, and that of compound 3 was determined by the TDDFT-ECD approach. Sclerotioloid A (1) represents the first example of 2,5-diketopiperazine alkaloid with a rare terminal alkyne. Sclerotioloid B (2) showed the inhibition of NO production induced by lipopolysaccharide (LPS), with an inhibition rate of 28.92% higher than that of dexamethasone (25.87%). These results expanded the library of fungal-derived alkaloids and further prove the potential of marine fungi in the generation of alkaloids with new scaffolds.

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Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi

Sharma,

Panjgotra,

Sharma

et al. 2024

Biotechnol Lett

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Exploring Potential of Aspergillus sclerotiorum: Secondary Metabolites and Biotechnological Relevance

Cited by 4 publications

References 82 publications

Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

Secondary Metabolites, Biological Activities, and Industrial and Biotechnological Importance of Aspergillus sydowii

Sclerotioloids A–C: Three New Alkaloids from the Marine-Derived Fungus Aspergillus sclerotiorum ST0501

Epigenetic modifiers as inducer of bioactive secondary metabolites in fungi

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