Exploring polysaccharide-based bio-adhesive topical film as a potential platform for wound dressing application: A review

Priya, Sakshi; Choudhari, Manisha; Tomar, Yashika; Desai, Vaibhavi Meghraj; Innani, Srinath; Dubey, Sunil Kumar; Singhvi, Gautam

doi:10.1016/j.carbpol.2023.121655

Cited by 9 publications

(3 citation statements)

References 126 publications

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“…Representative members of this class include sulfated glycosaminoglycans from animal connective tissue, namely: hyaluronic acid, sulfated galactans from red algae, alginic acid and its salts, pectins, and some hemicelluloses of plants [ 1 ]. These biopolymers, being active biocompatible systems, are capable of the prolonged controlled stimulation of reparative tissue regeneration [ 2 , 3 , 4 ]. Wound healing is induced by polysaccharides through the stimulation of cellular activity (cell motility, proliferation, and the synthesis of extracellular matrix of cytokines and growth factors).…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide Composite Alginate–Pectin Hydrogels as a Basis for Developing Wound Healing Materials

Davydova,

Chaikov,

Melnik

et al. 2024

Polymers

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This article presents materials that highlight the bioengineering potential of polymeric systems of natural origin based on biodegradable polysaccharides, with applications in creating modern products for localized wound healing. Exploring the unique biological and physicochemical properties of polysaccharides offers a promising avenue for the atraumatic, controlled restoration of damaged tissues in extensive wounds. The study focused on alginate, pectin, and a hydrogel composed of their mixture in a 1:1 ratio. Atomic force microscopy data revealed that the two-component gel exhibits greater cohesion and is characterized by the presence of filament-like elements. The dynamic light scattering method indicated that this structural change results in a reduction in the damping of acoustic modes in the gel mixture compared to the component gels. Raman spectroscopy research on these gels revealed the emergence of new bonds between the components’ molecules, contributing to the observed effects. The biocompatibility of the gels was evaluated using dental pulp stem cells, demonstrating that all the gels exhibit biocompatibility.

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Section: Introductionmentioning

confidence: 99%

Polysaccharide Composite Alginate–Pectin Hydrogels as a Basis for Developing Wound Healing Materials

Davydova,

Chaikov,

Melnik

et al. 2024

Polymers

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“…Traditional wound dressings, such as gauze, cotton, bandages, etc., have been widespreadly used in clinical treatment ( Wei et al, 2021 ; Priya et al, 2024 ). However, these traditional dressings lack antibacterial properties and need to be changed frequently, easily destroying new skin tissue due to easy adhere to tissue and increasing the risk of infection ( Zhou et al, 2022 ; Zhou et al, 2023a ).…”

Section: Introductionmentioning

confidence: 99%

Polyhydroxy structure orchestrates the intrinsic antibacterial property of acrylamide hydrogel as a versatile wound-healing dressing

Zhang,

Tang,

Zhang

et al. 2024

Front. Bioeng. Biotechnol.

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Hydrogel is considered as a promising candidate for wound dressing due to its tissue-like flexibility, good mechanical properties and biocompatibility. However, traditional hydrogel dressings often fail to fulfill satisfied mechanical, antibacterial, and biocompatibility properties simultaneously, due to the insufficient intrinsic bactericidal efficacy and the addition of external antimicrobial agents. In this paper, hydroxyl-contained acrylamide monomers, N-Methylolacrylamide (NMA) and N-[Tris (hydroxymethyl)methyl] acrylamide (THMA), are employed to prepare a series of polyacrylamide hydrogel dressings xNMA-yTHMA, where x and y represent the mass fractions of NMA and THMA in the hydrogels. We have elucidated that the abundance of hydroxyl groups determines the antibacterial effect of the hydrogels. Particularly, hydrogel 35NMA-5THMA exhibits excellent mechanical properties, with high tensile strength of 259 kPa and large tensile strain of 1737%. Furthermore, the hydrogel dressing 35NMA-5THMA demonstrates remarkable inherent antibacterial without exogenous antimicrobial agents owing to the existence of abundant hydroxyl groups. Besides, hydrogel dressing 35NMA-5THMA possesses excellent biocompatibility, in view of marginal cytotoxicity, low hemolysis ratio, and negligible inflammatory response and organ toxicity to mice during treatment. Encouragingly, hydrogel 35NMA-5THMA drastically promote the healing of bacteria-infected wound in mice. This study has revealed the importance of polyhydroxyl in the antibacterial efficiency of hydrogels and provided a simplified strategy to design wound healing dressings with translational potential.

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“…For hydrogel dressings, having the capability to adhere in wet conditions would be advantageous because the physiological environment is typically moist. 34 Therefore, there is an increasing interest in creating various wet adhesive methods customized to physiological conditions. Fortunately, nature provides many instances of organisms that can stick to wet surfaces, serving as inspirations for adhesive solutions.…”

Section: Introductionmentioning

confidence: 99%

An adhesion-switchable hydrogel dressing for painless dressing removal without secondary damage

Yu,

Huang,

Wang

et al. 2024

J. Mater. Chem. B

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Exploring polysaccharide-based bio-adhesive topical film as a potential platform for wound dressing application: A review

Cited by 9 publications

References 126 publications

Polysaccharide Composite Alginate–Pectin Hydrogels as a Basis for Developing Wound Healing Materials

Polysaccharide Composite Alginate–Pectin Hydrogels as a Basis for Developing Wound Healing Materials

Polyhydroxy structure orchestrates the intrinsic antibacterial property of acrylamide hydrogel as a versatile wound-healing dressing

An adhesion-switchable hydrogel dressing for painless dressing removal without secondary damage

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