Exploring polyamines: Functions in embryo/fetal development

Hussain, Tarique; Tan, Bin; Ren, Wenkai; Rahu, Najma; Kalhoro, Dildar Hussain; Yin, Yulong

doi:10.1016/j.aninu.2016.12.002

Cited by 34 publications

(28 citation statements)

References 56 publications

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“…Thus, NO might play a crucial role in maintaining adequate transfer of nutrients from mother to fetus. Likewise, polyamines regulate numerous cellular functions from gene expression to protein synthesis, which performs embryo/fetus proliferation, growth, and differentiation [28]. Furthermore, NO and polyamines are key regulators of angiogenesis.…”

Section: Arginine Nutrition In Pregnancy and Fetal Developmentmentioning

confidence: 99%

Impact of Arginine Nutrition and Metabolism during Pregnancy on Offspring Outcomes

Hsu

Tain

2019

Nutrients

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By serving as a precursor for the synthesis of nitric oxide, polyamines, and other molecules with biological importance, arginine plays a key role in pregnancy and fetal development. Arginine supplementation is a potential therapy for treating many human diseases. An impaired arginine metabolic pathway during gestation might produce long-term morphological or functional changes in the offspring, namely, developmental programming to increase vulnerability to developing a variety of non-communicable diseases (NCDs) in later life. In contrast, reprogramming is a strategy that shifts therapeutic interventions from adulthood to early-life, in order to reverse the programming processes, which might counterbalance the rising epidemic of NCDs. This review presented the role of arginine synthesis and metabolism in pregnancy. We also provided evidence for the links between an impaired arginine metabolic pathway and the pathogenesis of compromised pregnancy and fetal programming. This was followed by reprogramming strategies targeting the arginine metabolic pathway, to prevent the developmental programming of NCDs. Despite emerging evidence from experimental studies showing that targeting the arginine metabolic pathway has promise as a reprogramming strategy in pregnancy to prevent NCDs in the offspring, these results need further clinical application.

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Section: Arginine Nutrition In Pregnancy and Fetal Developmentmentioning

confidence: 99%

Impact of Arginine Nutrition and Metabolism during Pregnancy on Offspring Outcomes

Hsu

Tain

2019

Nutrients

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“…This, combined with structural brain anomalies in these patients, suggests a prenatal onset of this disorder. In fact, polyamines are known to play a key role in embryonal implantation, placentation, angiogenesis, and fetal development (Hussain et al, ). The specific effects of elevated putrescine levels in utero remain speculative.…”

Section: Discussionmentioning

confidence: 99%

Gain‐of‐function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

Rodan

Anyane‐Yeboa

Wassink-Ruiter

et al. 2018

American J of Med Genetics Pt A

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Polyamines serve a number of vital functions in humans, including regulation of cellular proliferation, intracellular signaling, and modulation of ion channels. Ornithine decarboxylase 1 (ODC1) is the rate-limiting enzyme in endogenous polyamine synthesis. In this report, we present four patients with a distinct neurometabolic disorder associated with de novo heterozygous, gain-offunction variants in the ODC1 gene. This disorder presents with global developmental delay, ectodermal abnormalities including alopecia, absolute or relative macrocephaly, and characteristic facial dysmorphisms. Neuroimaging variably demonstrates white matter abnormalities, prominent Virchow-Robin spaces, periventricular cysts, and abnormalities of the corpus callosum.Plasma clinical metabolomics analysis demonstrates elevation of N-acetylputrescine, the acetylated form of putrescine, with otherwise normal polyamine levels. Therapies aimed at reducing putrescine levels, including ODC1 inhibitors, dietary interventions, and antibiotics to reduce polyamine production by gastrointestinal flora could be considered as disease-modifying therapies. As the ODC1 gene has been implicated in neoplasia, cancer surveillance may be important in this disorder. K E Y W O R D S alopecia, neurodevelopmental disorder, ornithine decarboxylase 1 (ODC1), polyamines, putrescine

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“…Ornithine degradation is a very important process in polyamine metabolism which has dire implications in early embryogenesis, implantation and is associated with some reproductive conditions such as intra‐uterine growth retardation (IUGR), reviewed extensively by Hussain et al. (). However, the involvement of sperm genome in polyamine metabolism in early embryo is not clear.…”

Section: Discussionmentioning

confidence: 99%

Systemic hormonal modulation induces sperm nucleosomal imbalance in rat spermatozoa

2018

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Sperm chromatin packaging is a very complex and highly regulated phenomenon. While most of the sperm chromatin is replaced by protamines, some are retained in nucleosomes. It is recently being recognised that these nucleosomes are intentionally retained and could be contributing to the expression of genes in the very early stages of embryogenesis. Endocrine disruption has been previously shown to affect reproductive outcome and sperm DNA methylation. This study aims to decipher the possibility of changes in nucleosome occupancy in sperm chromatin, induced by tamoxifen (selective oestrogen receptor modulator) and cyproterone acetate (androgen antagonist). We used next-generation sequencing approach (MNase-Seq) to identify changes in the nucleosome landscape of the spermatozoa. We demonstrated that endocrine disruption affects nucleosome occupancy at critical regions of the genome and many of them harbour genes relevant for embryogenesis. This study emphasises that environmental factors could affect embryo development by way of modulating male epigenetic factors.

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Exploring polyamines: Functions in embryo/fetal development

Cited by 34 publications

References 56 publications

Impact of Arginine Nutrition and Metabolism during Pregnancy on Offspring Outcomes

Impact of Arginine Nutrition and Metabolism during Pregnancy on Offspring Outcomes

Gain‐of‐function variants in the ODC1 gene cause a syndromic neurodevelopmental disorder associated with macrocephaly, alopecia, dysmorphic features, and neuroimaging abnormalities

Systemic hormonal modulation induces sperm nucleosomal imbalance in rat spermatozoa

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