Exploring patients' adherence to antibiotics by understanding their health knowledge and relational communication in encounters with pharmacists and physicians

Bergsholm, Yngvild Kristine Rochette; Feiring, Marte; Charnock, Colin; Holm, Lene Berge; Krogstad, Tonje

doi:10.1016/j.rcsop.2023.100372

Cited by 1 publication

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References 65 publications

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“…It is associated with increased healthcare costs [ 2 ], morbidity [ 3 ], and mortality [ 4 ]. As an example, poor adherence to antibiotic therapy contributes to the risk of increasing antimicrobial resistance with all of its associated consequences [ 5 ]. Thus, healthcare providers need accurate estimates of individual patients’ medication-taking behavior to ameliorate this problem and develop tailored interventions aimed at improving medication adherence.…”

Section: Introductionmentioning

confidence: 99%

Inconclusiveness of psychometric testing of medication adherence questionnaires

Arnet,

Eickhoff,

Sahm

et al. 2024

Eur J Clin Pharmacol

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Purpose To propose a paradigm change for the validation procedures of medication adherence questionnaires. Methods A total of 121 validation procedures of unique questionnaires for medication adherence were analyzed. Results “Construct validity” and “internal consistency” were most often assessed, and test results varied largely. A more in-depth analysis indicated that the assessment of medication non-adherence included distinct but related constructs, such as the extent to which doses are missed, and the attempt to identify different facets of medication-taking behavior. Consequently, each construct requires a different measurement approach with different psychometric tests for establishing its validity and reliability. Conclusion Results show that assessing the validity and reliability of adherence questionnaires with standard procedures including statistical tests is inconclusive. Refinement of the constructs of non-adherence is needed in pharmacy and medical practice. We suggest a distinction between the (i) extent of missed doses over the past 2 weeks, (ii) modifiable reasons for non-adherence behavior, and (iii) unmodifiable factors of non-adherence. Validation procedures and corresponding statistical methods should be selected according to the specific single constructs.

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