Exploring pancreatic beta-cell subgroups and their connectivity
Guy A. Rutter,
Anne Gresch,
Luis Delgadillo Silva
et al.
Abstract:Functional pancreatic islet beta cells are essential to ensure glucose homeostasis across species from zebrafish to humans. These cells show significant heterogeneity, and emerging studies have revealed that connectivity across a hierarchical network is required for normal insulin release. Here, we discuss current thinking and areas of debate around intra-islet connectivity, cellular hierarchies and potential “controlling” beta-cell populations. We focus on methodologies, including comparisons of different cel… Show more
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