Exploring Novel Genome Instability-associated lncRNAs and their
Potential Function in Pan-Renal Cell Carcinoma
Hui-Xin Zhu,
Wen-Cai Zheng,
Hang Chen
et al.
Abstract:aims:
Genomic instability can drive clonal evolution, continuous modification of
tumor genomes, and tumor genomic heterogeneity. The molecular mechanism of genomic instability
still needs further investigation. This study aims to identify novel genome instabilityassociated
lncRNAs (GI-lncRNAs) and investigate the role of genome instability in pan-Renal
cell carcinoma (RCC).
Materials and Methods::
A mutator hypothesis was employed, combining the TCGA database
of somatic mutation (SM) information, to identify… Show more
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