Exploring novel dilazep derivatives as hENT1 inhibitors and potentially covalent molecular tools
Majlen A. Dilweg,
Marina Gorostiola González,
Martijn D. de Ruiter
et al.
Abstract:The human equilibrative nucleoside transporter 1 (SLC29A1, hENT1) is a solute carrier that modulates the passive transport of nucleosides and nucleobases, such as adenosine. This nucleoside regulates various physiological processes, such as vasodilation and -constriction, neurotransmission and immune defense. Marketed drugs such as dilazep and dipyridamole have proven useful in cardiovascular afflictions, but the application of hENT1 inhibitors can be beneficial in a number of other diseases. In this study, 39… Show more
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