Exploring novel bioactive compounds from marine microbes

Isolation and characterization of potential antibiotic producing actinomycetes from water and sediments of Lake Tana, Ethiopia

“…The sediment samples were air dried; heated aseptically, which stimulates the isolation of actinomycetes by eliminating most unwanted Gram negative bacteria. Appropriate selective media such as starch casein agar, glycerol yeast extract agar and antifungal antibiotics (amphotericin B) at 25 µg/mL were used for actinomycetes growth promotion and also for prevention of fungal contamination [26,27] .…”

Verrucosispora sediminis sp. nov., a cyclodipeptide-producing actinomycete from deep-sea sediment

“…Novel microbes and their associated bioactive compounds have been isolated (Demain & Zhang, 2005). Since the description of the marine genus Salinispora and its bioactive secondary metabolites, marine actinomycetes, especially members of the family Micromonosporaceae, have received attention from both taxonomists and chemists (Maldonado et al, 2005;Laatsch, 2006;Lam, 2006;Knight et al, 2003;Zhang et al, 2005). The discovery of abyssomicin, an inhibitor of p-aminobenzoic acid biosynthesis, in the marine strain AB-18-032 of the genus Verrucosispora has led to this genus receiving special attention (Riedlinger et al, 2004).…”

Characterization of cytotoxic compound from mangrove derived fungi Irpex hydnoides VB4

“…Problems related to human health such as the development of drug resistance in human pathogenic bacteria, fungal infections, and life threatening virus claim for new therapeutic agents for effective treatment of diseases in human, plants, and animals that are currently unmet [19] .…”