Exploring NK cell receptor dynamics in paediatric leukaemias: implications for immunotherapy and prognosis
Cui Tu,
Irina Buckle,
Ingrid Leal Rojas
et al.
Abstract:ObjectivesImmunotherapies targeting natural killer (NK) cell receptors have shown promise against leukaemia. Unfortunately, cancer immunosuppressive mechanisms that alter NK cell phenotype prevent such approaches from being successful. The study utilises advanced cytometry to examine how cancer immunosuppressive pathways affect NK cell phenotypic changes in clinical samples.MethodsIn this study, we conducted a high‐dimensional examination of the cell surface expression of 16 NK cell receptors in paediatric pat… Show more
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