Exploring nanocarriers as innovative materials for advanced drug delivery strategies in onco-immunotherapies

Tiwari, Pratiksha; Shukla, Ravi Prakash; Yadav, Krishna; Panwar, Dilip; Agarwal, Neha; Kumar, Ankit; Singh, Neha; Bakshi, Avijit Kumar; Marwaha, Disha; Gautam, Shalini; Rai, Nikhil; Mishra, Prabhat Ranjan

doi:10.1016/j.jmgm.2024.108702

Cited by 9 publications

(1 citation statement)

References 190 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The solutions, suspensions, emulsions, and gels are still used in visual disease treatment . As of now, due to ease of administration, eye drops are the most accepted and widely used dosage form among other conventional dosage forms (suspension, gel, emulsions, and ointment) for treating a broad range of eye disorders. , Some key factors should be considered while preparing the formulation, including the appropriate selection of the drug and its salt, solvent solubility, ocular toxicity, and the effect of the pH on the formulation. − Other than this, the solution should be isotonic and should not be highly viscous, within the ocular buffering capacity, free from the interaction between the drug and selected excipients, choice of appropriate preservatives, ocular safety, and dosing administration. However, they have a few drawbacks, such as low bioavailability because of their physical attributes, such as irritable macroparticles, low penetration ability, less residence time at the ocular surface, lack of drug delivery to the posterior segment, and most drug wash-off because of tear dilution and turnover tend to frequent administration, which reduces patient compliance.…”

Section: Limitations Of Current Therapymentioning

confidence: 99%

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Bisen,

Sanap,

Agrawal

et al. 2024

ACS Infect. Dis.

View full text Add to dashboard Cite

Fungal keratitis (FK) is a severe ocular condition resulting from corneal infection that is prevalent in tropical countries, particularly in developing regions of Asia and Africa. Factors like corneal lens misuse, inappropriate steroid use, and diagnostic challenges have provoked the epidemic. FK causes significant vision impairment, scarring, and ocular deformities. Accurate pathological diagnosis is crucial for effective therapeutic intervention. Topical antifungal therapy with surface healing medications proves effective in preventing fungal-borne ulcers. Managing FK requires a comprehensive understanding of fungal pathogenesis, guiding formulation strategies and preventive measures to curb global ocular blindness. This review provides in-depth insights into FK, covering etiology, epidemiology, pathogenesis, therapeutic interventions, antifungal resistance, limitations, prevention, and future perspectives on ocular surface disease management.

show abstract

Section: Limitations Of Current Therapymentioning

confidence: 99%

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Bisen,

Sanap,

Agrawal

et al. 2024

ACS Infect. Dis.

View full text Add to dashboard Cite

show abstract

Polymers and their engineered analogues for ocular drug delivery: Enhancing therapeutic precision

Biswas,

Kumar,

Choudhury

et al. 2024

Biopolymers

View full text Add to dashboard Cite

Ocular drug delivery is constrained by anatomical and physiological barriers, necessitating innovative solutions for effective therapy. Natural polymers like hyaluronic acid, chitosan, and gelatin, alongside synthetic counterparts such as PLGA and PEG, have gained prominence for their biocompatibility and controlled release profiles. Recent strides in polymer conjugation strategies have enabled targeted delivery through ligand integration, facilitating tissue specificity and cellular uptake. This versatility accommodates combined drug delivery, addressing diverse anterior (e.g., glaucoma, dry eye) and posterior segment (e.g., macular degeneration, diabetic retinopathy) afflictions. The review encompasses an in‐depth exploration of each natural and synthetic polymer, detailing their individual advantages and disadvantages for ocular drug delivery. By transcending ocular barriers and refining therapeutic precision, these innovations promise to reshape the management of anterior and posterior segment eye diseases.

show abstract

Codetermination of antimicrobial agents in rabbit tear fluid using LC–MS/MS assay: Insights into ocular pharmacokinetic study

Bisen,

Mishra,

Agrawal

et al. 2024

J Mass Spectrom

View full text Add to dashboard Cite

Managing ocular microbial infections typically requires pharmacotherapy using antibiotic eye drops, such as moxifloxacin hydrochloride (MFX), combined with an antifungal agent like amphotericin B (AB). We carried out and validated an LC–MS/MS assay to quantify these compounds in rabbit tear fluid in order to look into the pharmacokinetics of these two drugs. We employed a protein precipitation technique for the extraction of drugs under examination. A Waters Symmetry C18 column was used to separate the analytes and internal standard. The composition of the mobile phase was like (A) 0.1% v/v formic acid in water and (B) methanol. The detection of MFX and AB was accomplished through the utilization of positive ion electrospray ionization under multiple reaction monitoring mode. The linearity curves for both analytes exhibited an acceptable trendline across a concentration range of 2.34–300 ng/mL for MFX and 7.81–1000 ng/mL for AB in surrogate rabbit tear fluid. The lower limit of quantitation for MFX was 2.34 ng/mL, while for AB, it was 7.81 ng/mL. The approach was strictly validated, encompassing tests of selectivity, linearity (with r2 > 0.99), precision, accuracy, matrix effects, and stability. Consequently, we employed this method to evaluate the pharmacokinetics profiles of MFX and AB in rabbit tear fluid following single topical doses.

show abstract

Exploring nanocarriers as innovative materials for advanced drug delivery strategies in onco-immunotherapies

Cited by 9 publications

References 190 publications

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Etiopathology, Epidemiology, Diagnosis, and Treatment of Fungal Keratitis

Polymers and their engineered analogues for ocular drug delivery: Enhancing therapeutic precision

Codetermination of antimicrobial agents in rabbit tear fluid using LC–MS/MS assay: Insights into ocular pharmacokinetic study

Contact Info

Product

Resources

About