Exploring Molecular Insights of Cereal Peptidic Antioxidants in Metabolic Syndrome Prevention

Abstract

The prevalence of metabolic syndrome (MetS) is presently an alarming public health problem globally. Oxidative stress has been postulated to be strongly correlated with MetS, such as type 2 diabetes, obesity, hypertension, cardiovascular diseases, and certain cancers. Cereals are important staple foods which account for a huge proportion of the human diet. However, owing to recent growing demand and the search for natural antioxidants for the prevention and management of MetS, cereal peptides have gained increasing attention for developing functional ingredients or foods with substantial antioxidant properties. This review explores the current production techniques for cereal peptidic antioxidants and their potential mechanism of action in the prevention and management of MetS.

Raman Fingerprints of Rice Nutritional Quality: A Comparison between Japanese Koshihikari and Internationally Renowned Cultivars

“…Rice albumin has been found to suppress the elevation of blood glucose and plasma insulin levels after oral glucose loading [ 61 ]. Regarding the antioxidant properties, rice albumin was found to provide a potent antioxidant action against low-density lipoprotein oxidation and maintained this property unchanged after digestion with trypsin and chymotrypsin [ 62 ]. In conclusion, the relatively high level of albumin of the Koshihikari cultivar could partly compensate for its relatively high glycemic impact due to an elevate content of amylopectin (cf.…”

Improving the Treatment Effect of Carotenoids on Alzheimer’s Disease through Various Nano-Delivery Systems

“…Naturally, oxidative stress (OS) is a major feature of AD. The reasons why neurons are extremely sensitive to OS include the following: (1) the energy generated by oxidative phosphorylation in neuronal mitochondria is extremely important [37,38]; (2) about 20% of the oxygen generated by respiration is used by neurons, 1-2% of which is converted into reactive oxygen species to cause OS [39][40][41][42]; (3) metal ions in neurons accumulate and catalyze ROS production in the brain as the aging process progresses [43]; (4) polyunsaturated fatty acids in neurons are susceptible to oxidation [44]; and (5) neurons have relatively low levels of antioxidants and related enzymes [45,46]. In general, OS level increases with age and is an important factor in inducing AD.…”

Millet Bran Protein Hydrolysate Displays the Anti-non-alcoholic Fatty Liver Disease Effect via Activating Peroxisome Proliferator-Activated Receptor γ to Restrain Fatty Acid Uptake

“…Nishizawa et al found that grain proteins exhibited a significant antiatherogenic effect through increasing the plasma concentrations of high-density lipoprotein (HDL) . The research of Ofosu et al showed that the active peptides derived from cereal can alleviate metabolic syndrome, such as type 2 diabetes, obesity, hypertension, cardiovascular diseases, and certain cancers . Therefore, the increasing intake of whole grains in the diet may be an effective strategy for prevention and treatment of NAFLD.…”