2023
DOI: 10.1007/s10529-023-03407-6
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Exploring l-isoleucine riboswitches for enhancing 4-hydroxyisoleucine production in Corynebacterium glutamicum

Abstract: ObjectivesTo explore an L-isoleucine (Ile)-induced biosensor for down-regulation of Ile synthesis pathway and enhancement of 4-hydroxyisoleucine (4-HIL) production in Corynebacterium glutamicum SN01. ResultsFour Ile-induced riboswitches (IleRSN) with different strength were screened from mutation library based on TPP riboswitch. Firstly, IleRSN were integrated into the chromosome of strain SN01 immediately upstream of ilvA gene. The 4-HIL titer of strains carrying P tacM -driven IleRS1 or IleRS3 (14.09±1.07, 1… Show more

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