Exploring inspiratory occlusion metrics to assess respiratory drive in patients under acute intermittent hypoxia

Rodrigues, Victoria R.; Olsen, Wendy L.; Sajjadi, Elaheh; Smith, Barbara K.; Napoli, Nicholas J.

doi:10.1016/j.resp.2022.103922

Cited by 1 publication

(1 citation statement)

References 27 publications

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“…Further, the authors posited that compensatory responses to inspiratory occlusions may provide additional insights into the ability of patients to quickly generate pressure when challenged. 137 As indicated previously, the tAIH “dose” is critical for promoting serotonergic signaling, while avoiding negative effects of severe hypoxia. While some clinical trials have used commercially available altitude simulators to deliver tAIH, the intervention requires supervision for vital sign monitoring and patient tolerance.…”

Section: Therapeutic Acute Intermittent Hypoxia (Taih)mentioning

confidence: 90%

Respiratory therapies for Amyotrophic Lateral Sclerosis: A state of the art review

et al. 2023

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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative condition noteworthy for upper and lower motor neuron death. Involvement of respiratory motor neuron pools leads to progressive pathology. These impairments include decreases in neural activation and muscle coordination, progressive airway obstruction, weakened airway defenses, restrictive lung disease, increased risk of pulmonary infections, and weakness and atrophy of respiratory muscles. These neural, airway, pulmonary, and neuromuscular changes deteriorate integrated respiratory-related functions including sleep, cough, swallowing, and breathing. Ultimately, respiratory complications account for a large portion of morbidity and mortality in ALS. This state-of-the-art review highlights applications of respiratory therapies for ALS, including lung volume recruitment, mechanical insufflation-exsufflation, non-invasive ventilation, and respiratory strength training. Therapeutic acute intermittent hypoxia, an emerging therapeutic tool for inducing respiratory plasticity will also be introduced. A focus on emerging evidence and future work underscores the common goal to continue to improve survival for patients living with ALS.

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Section: Therapeutic Acute Intermittent Hypoxia (Taih)mentioning

confidence: 90%