Exploring genetic associations between allergic diseases and indicators of COVID-19 using mendelian randomization

Wang, Yujie; Gu, Xiaoyu; Wang, X; Zhu, Wu; Su, Juan

doi:10.1016/j.isci.2023.106936

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…The advantage of MR is that genetic variants are established at birth, reducing confounding factors and reverse causation issues common in traditional observational studies [18,19,21]. Using single nucleotide polymorphisms (SNPs) associated with the risk of severe COVID-19 or pre-eclampsia as instrumental variables, MR analysis can provide robust evidence for the potential causal relationship between these diseases [22,23]. Genetic epidemiology studies can also help identify genetic correlations, further understanding their pathophysiological basis and shared molecular mechanisms [24].…”

Section: Introductionmentioning

confidence: 99%

Exploring the Genetic Link Between COVID-19 Severity and Pre-eclampsia: The Role of NTSR1 Gene SNPs and Calcium Ion Transport

Li,

Shen,

Zheng

et al. 2024

Preprint

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Introduction: The COVID-19 pandemic and pre-eclampsia both present significant health challenges worldwide, with emerging evidence suggesting a genetic interlinkage that could illuminate new therapeutic avenues. This study aims to explore the genetic relationship between the severity of COVID-19 and pre-eclampsia, with a focus on Single Nucleotide Polymorphisms (SNPs) in the NTSR1 gene and mechanisms of calcium ion transport. Method: We employed a combination of genetic epidemiology and molecular biology techniques, including comprehensive bibliometric analysis and Mendelian Randomization, to assess the correlation between specific SNPs related to the NTSR1 gene and the severity of both COVID-19 and pre-eclampsia. Result: Our findings reveal a significant genetic correlation between the severity of COVID-19 and pre-eclampsia, underscored by SNPs associated with the NTSR1 gene and calcium ion transport. This correlation suggests a shared genetic foundation that could exacerbate both conditions, providing insights into potential molecular interactions involved. Conclusion: The identification of shared genetic pathways between COVID-19 and pre-eclampsia highlights the importance of genetic insights in developing targeted therapeutic interventions. These results open up new avenues for the mitigation of these conditions, emphasizing the role of genetic epidemiology in shaping future healthcare strategies.

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Section: Introductionmentioning

confidence: 99%

Exploring the Genetic Link Between COVID-19 Severity and Pre-eclampsia: The Role of NTSR1 Gene SNPs and Calcium Ion Transport

Li,

Shen,

Zheng

et al. 2024

Preprint

View full text Add to dashboard Cite

show abstract

“…Based on publically accessible and reputable genome‐wide association studies (GWAS) data, MR employs single nucleotide polymorphisms (SNPs) as an instrumental variable (IV) to deduce a causal relationship between an exposure and an outcome. In previous studies, many research groups have used the MR method to elucidate the causal associations between COVID‐19 and medical conditions such as gout, 17 diabetes, 18 and allergy disorders 19 . The research above provides compelling data on the multiorgan damage caused by COVID‐19, which has significant value in facilitating early diagnosis and therapy within clinical settings.…”

Section: Introductionmentioning

confidence: 99%

“…In previous studies, many research groups have used the MR method to elucidate the causal associations between COVID-19 and medical conditions such as gout, 17 diabetes, 18 and allergy disorders. 19 The research above provides compel- with respiratory failure, and critical COVID-19). The outcome chosen was pancreatitis, which includes AP, CP, AAP, and ACP.…”

mentioning

confidence: 99%

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

Ge,

Luo,

Liu

et al. 2023

Journal of Medical Virology

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The impact of severe acute respiratory syndrome coronavirus 2 infection on the potential development of pancreatitis is a subject of ongoing debate within academic discourse. Establishing a causal link between COVID‐19 and pancreatitis may not be fully supported by relying only on retrospective studies or case reports. This study examined the relationship between COVID‐19 phenotypes and pancreatitis by Mendelian randomization (MR) method. The identification of instrumental variables (single nucleotide polymorphisms) that exhibit a robust association with the COVID‐19 phenotypes was accomplished through a meticulous process of rigorous screening procedures. We included acute pancreatitis and chronic pancreatitis (CP) as the outcomes in the MR analysis, even though no definitive studies exist between COVID‐19 and CP. A direct causal relationship between genetically predicted COVID‐19 phenotypes and pancreatitis risk cannot be established. There is an ongoing debate over the designation of COVID‐19 as a definitive cause of pancreatitis.

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No causal association between allergic rhinitis and migraine: a Mendelian randomization study

Lv,

Liu,

Xie

et al. 2024

Eur J Med Res

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Purpose Allergic rhinitis (AR) and migraine are among the most common public health problems worldwide. Observational studies on the correlation between AR and migraine have reported inconsistent results. This study aimed to investigate the causal relationship of AR with migraine and its subtypes, including migraine with aura (MA) and migraine without aura (MO). Methods Bidirectional two-sample Mendelian randomization (MR) analysis was performed with publicly available summary-level statistics of large genome-wide association studies to estimate the possible causal effects. The inverse variance-weighted method was selected for primary analysis and was supplemented with the weighted median, weighted mode, and MR-Egger methods. The causal analysis using summary effect estimates (CAUSE) were further performed to verify the causality. Several sensitivity tests, including the leave-one-out, Cochran’s Q, MR-Egger intercept, and MR-PRESSO tests, were performed to assess the robustness of the results. Results AR did not exhibit a significant causal correlation with the elevated risk of any migraine (odd ratio (OR), 0.816; 95% confidence interval (CI), 0.511–1.302; P = 0.394), MA (OR, 0.690; 95% CI 0.298–1.593; P = 0.384), or MO (OR, 1.022; 95% CI 0.490–2.131; P = 0.954). Consistently, reverse MR analysis did not reveal causal effects of any migraine or its subtypes on AR. Almost all sensitivity analyses supported the robustness of the results. Conclusions This MR study did not reveal a clear causal association between AR and migraine risk. More research is warranted to reveal the complex association between AR and migraine.

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Exploring genetic associations between allergic diseases and indicators of COVID-19 using mendelian randomization

Cited by 4 publications

References 24 publications

Exploring the Genetic Link Between COVID-19 Severity and Pre-eclampsia: The Role of NTSR1 Gene SNPs and Calcium Ion Transport

Exploring the Genetic Link Between COVID-19 Severity and Pre-eclampsia: The Role of NTSR1 Gene SNPs and Calcium Ion Transport

Eliminating COVID‐19 as the immediate culprit for igniting pancreatitis

No causal association between allergic rhinitis and migraine: a Mendelian randomization study

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