Exploring gaps in our knowledge on Lyme borreliosis spirochaetes – Updates on complex heterogeneity, ecology, and pathogenicity

Franke, Jan; Hildebrandt, Anke; Dorn, Wolfram

doi:10.1016/j.ttbdis.2012.06.007

Cited by 115 publications

(130 citation statements)

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“…Additionally, B. bissettii infection and pathology have been reported in laboratory animals (Eisen et al, 2003;Schneider et al, 2008). Apart from these studies and general molecular surveys in ticks and wildlife (reviewed by Franke et al, 2013), our understanding of B. bissettii, as well as most non-B. burgdorferi ss in the US, is still in its infancy.…”

Section: Introductionmentioning

confidence: 99%

Similarities in murine infection and immune response to Borrelia bissettii and Borrelia burgdorferi sensu stricto

Leydet

Liang

2015

Microbiology

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In 1982, Borrelia burgdorferi sensu stricto (ss) was identified as the aetiological agent of Lyme disease. Since then an increasing number of Borrelia burgdorferi sensu lato (sl) species have been isolated in the United States. To date, many of these species remain understudied despite mounting evidence associating them with human illness. Borrelia bissettii is a spirochaete closely related to B. burgdorferi that has been loosely associated with human illness. Using an experimental murine infection model, we compared the infectivity and humoral immune response with a North American isolate of B. bissettii and B. burgdorferi using culture, molecular and serological methods. The original B. bissettii cultures were unable to infect immunocompetent mice, but were confirmed to be infectious after adaptation in immunodeficient animals. B. bissettii infection resulted in spirochaete burdens similar to B. burgdorferi in skin, heart and bladder whereas significantly lower burdens were observed in the joint tissues. B. bissettii induced an antibody response similar to B. burgdorferi as measured by both immunoblotting and the C6 ELISA. Additionally, this isolate of B. bissettii was sequenced on the Ion Torrent PGM, which successfully identified many genes orthologous to mammalian virulence factors described in B. burgdorferi. Similarities seen between both infections in this well-characterized murine model contribute to our understanding of the potential pathogenic nature of B. bissettii. Infection dynamics of B. bissettii, and especially the induced humoral response, are similar to B. burgdorferi, suggesting this species may contribute to the epidemiology of human borreliosis. INTRODUCTIONIn 1982, the causative agent of Lyme disease was isolated from an Ixodes scapularis tick (Burgdorfer et al., 1982). The bacterium, a spirochaete, was named Borrelia burgdorferi after Willy Burgdorfer, one of the researchers who identified it. Three decades after this discovery, advancements in molecular biology have led to the delineation of the B. burgdorferi sensu lato (sl) species complex (Stanek & Reiter, 2011). This complex comprises, at the time of writing, 18 named species distributed around the globe (Kurtenbach et al., 2006;Margos et al., 2011). While genetically similar, many of these bacteria occur in specific tick-vertebrate enzootic cycles (Gray et al., 2002). Some vector ticks commonly contact humans (Estrada-Peña & Jongejan, 1999), but many of these Borrelia enzootic cycles involve ticks that rarely bite humans, which subsequently leaves the pathogenicity of many B. burgdorferi sl species in question (Kiewra & Lonc, 2012;Margos et al., 2012).In 2011, 33 000 cases of human Lyme disease were reported to the Centers for Disease Control (CDC, 2011). Yet, recently the CDC has announced they estimate this statistic is well below the actual number of diagnosed cases (*300 000 year) (Hinckley et al., 2014). Although seven B. burgdorferi sl species have been isolated in culture in North America only B. burgdorferi sensu stricto (...

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Section: Introductionmentioning

confidence: 99%

Similarities in murine infection and immune response to Borrelia bissettii and Borrelia burgdorferi sensu stricto

Leydet

Liang

2015

Microbiology

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“…[12]. Na podstawie pochodzenia filogenetycznego wśród krętków z rodzaju Borrelia wyróżnia się 3 grupy [13] …”

Section: Wyniki Przegląduunclassified

“…stosowane w laboratoriach różna metodyka i materiały kontrolne, a także brak standaryzacji Ag diagnostycznych wobec zróżnicowania gatunkowego krętków Borrelia spp. Liczne są też czynniki powodują-ce równie częste występowanie wyników fałszywie dodatnich i fałszywie ujemnych [13,23].…”

Section: Kurtenbachii)unclassified

Tick-borne diseases in Poland: Prevalence and difficulties in diagnostics

Kmieciak¹,

Ciszewski²,

Szewczyk³

2016

Med Pr

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StreszczenieW artykule przedstawiono zagadnienia dotyczące diagnostyki chorób odkleszczowych w Polsce, które stanowią obecnie jedną z grup chorób zawodowych o najszerszym zasięgu na terenie naszego kraju. Problem ten jest aktualny z uwagi na stale rosną-cą liczbę przypadków zachorowań na choroby odkleszczowe (m.in. boreliozę z Lyme, odkleszczowe zapalenie mózgu, tularemię, gorączkę Q, ludzką anaplazmozę granulocytarną, babeszjozę). Odzwierciedlają ten stan zwłaszcza ostatnie meldunki epidemiologiczne Narodowego Instytutu Zdrowia Publicznego -Państwowego Zakładu Higieny (NIZP -PZH) w Warszawie. W niniejszym artykule zawarto również informacje dotyczące taksonomii wektorów poszczególnych czynników etiologicznych chorób tej grupy i ich rezerwuarów oraz możliwości transmisji przedstawionych drobnoustrojów. Ryzyko zakażenia nimi dotyczy szczególnie osób przebywających na terenach leśno-łąkowych w celach zarówno rekreacyjnych, jak i zawodowych (pracowników terenów leśnych, rolników, osób związanych z łowiectwem). Artykuł zawiera najnowsze dane z zakresu epidemiologii, etiopatogenezy, symptomatologii, diagnostyki laboratoryjnej i wpływających na nią czynników, opracowane z uwzględnieniem obowiązują-cych na terenie Polski zaleceń Polskiego Towarzystwa Epidemiologów i Lekarzy Chorób Zakaźnych oraz rekomendacji Krajowej Izby Diagnostów Laboratoryjnych. Szczególny nacisk położono na problematykę współczesnych metod laboratoryjnych wykorzystywanych w trudnej diagnostyce chorób odkleszczowych z uwzględnieniem algorytmów diagnostycznych oraz fazy przedanalitycznej (rodzaj materiału biologicznego) i analitycznej tych badań (metody referencyjne, skuteczność poszczególnych technik, czynniki interferujące, prawidłowość postępowania diagnostycznego). Med. Pr. 2016;67(1):73-87 Słowa kluczowe: epidemiologia, boreliozy, zoonozy, kleszcze, przenosiciele chorób, kliniczne techniki laboratoryjne AbstractThe article presents an overview of diagnostics of tick-borne diseases in Poland, which form one of the most prevalent group of occupational illnesses in the Polish area. This is a current issue due to a constantly growing number of tick-borne infections, i.e., Lyme borreliosis, tick-borne encephalitis, tularemia, Q fever, human granulocytic anaplasmosis and babesiosis. The scale of the problem is well illustrated by the latest reports of the Polish National Institute of Public Health -National Institute of Hygiene (NIPH -NIH). The article also covers the taxonomy of vectors of etiological factors, as well as their reservoirs and possible transmission to humans. The highest risk of tick-borne infection is particularly connected with people either resting or working in the forest or meadow surroundings (i.e., foresters, farmers, hunters). The article contains up-to-date data on epidemiology, etiopathogenesis, symptomatology, laboratory medicine and factors affecting the credibility of results according to current recommendations of the Polish Society of Epidemiology and Physicians of Infectious Diseases and the Polish National Chamber of ...

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“…Although there have been several studies carried out on particular sites 72 or on various classes of vertebrates 73 , and some descriptive reviews have been published 62,74,75 , there is no quantitative review that integrates data on a host assemblage comprising a wide range of vertebrate species. Here, we used a data driven approach to quantify the contribution of various vertebrate host species to feeding I. ricinus ticks, and transmitting B. burgdorferi to feeding larvae, to infer a mechanism that could support the apparent increase in Lyme borreliosis incidence in Europe.…”

Section: Introductionmentioning

confidence: 99%

The wild life of tick-borne pathogens

Hofmeester

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Exploring gaps in our knowledge on Lyme borreliosis spirochaetes – Updates on complex heterogeneity, ecology, and pathogenicity

Cited by 115 publications

References 218 publications

Similarities in murine infection and immune response to Borrelia bissettii and Borrelia burgdorferi sensu stricto

Similarities in murine infection and immune response to Borrelia bissettii and Borrelia burgdorferi sensu stricto

Tick-borne diseases in Poland: Prevalence and difficulties in diagnostics

The wild life of tick-borne pathogens

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