Exploring epigenetic drift and rare epivariations in amyotrophic lateral sclerosis by epigenome-wide association study
Alberto Brusati,
Silvia Peverelli,
Luciano Calzari
et al.
Abstract:During the last decades, our knowledge about the genetic architecture of sporadic amyotrophic lateral sclerosis (sALS) has significantly increased. However, besides the recognized genetic risk factors, also the environment is supposed to have a role in disease pathogenesis. Epigenetic modifications reflect the results of the interaction between environmental factors and genes and may play a role in the development and progression of ALS. A recent epigenome-wide association study (EWAS) in blood identified diff… Show more
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