Exploring electrophysiological correlates of social cognition in subclinical schizotypy

Abstract

Impairments in social cognition and associated abnormalities in brain function are well documented in psychotic disorders. They may represent neurodevelopmental vulnerabilities and may therefore be present in less severe or even subclinical conditions of the schizophrenia spectrum, such as schizotypy. Schizotypy has features highly suggestive of social cognitive impairments, but little is known about possible related abnormalities of brain function. This exploratory pilot study examines electrophysiological event-related potentials (ERPs) implicated in schizophrenia, in 23 undergraduates with a range of subclinical schizotypal characteristics. ERPs were recorded in response to emotional face stimuli in an experimental paradigm designed to assess very early stages of social stimulus processing. Three ERPs were assessed, P100, N170 and P300. P100 and P300 were found to be related to multiple schizotypal features, but N170 was not. The results support occurrence of social cognitive impairments linked to abnormal brain function across the schizophrenia spectrum. Copyright © 2018 John Wiley & Sons, Ltd.

P300 in schizophrenia: Then and now

“…Of note, a few studies in the general population have also reported an association between reduced P300 amplitudes and schizotypal features (Davidson et al, 2018;Deng et al, 2023;Klein et al, 1999), which may reflect a genetic vulnerability for psychosis (e.g., Lenzenweger, 2018).…”