Exploring early DNA methylation alterations in type 1 diabetes: implications of glycemic control
Barbara Čugalj Kern,
Jernej Kovač,
Robert Šket
et al.
Abstract:BackgroundProlonged hyperglycemia causes diabetes-related micro- and macrovascular complications, which combined represent a significant burden for individuals living with diabetes. The growing scope of evidence indicates that hyperglycemia affects the development of vascular complications through DNA methylation.MethodsA genome-wide differential DNA methylation analysis was performed on pooled peripheral blood DNA samples from individuals with type 1 diabetes (T1D) with direct DNA sequencing. Strict selection… Show more
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