Exploring DNA binding and nucleolytic activity of few 4-aminoantipyrine based amino acid Schiff base complexes: A comparative approach

Raman, Natarajan; Sakthivel, A.; Pravin, Narayanaperumal

doi:10.1016/j.saa.2014.01.108

Cited by 47 publications

(19 citation statements)

References 31 publications

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“…So it seems worthwhile to compare the antibacterial properties of 1 with copper complexes derived from quinolones. The activity of complex 1 was found to be even higher than some reported 3-carboxy-4-quinolone copper complexes against the same bacterial strain P. aeruginosa (100 lg/mL) [35] but less compared to copper complexes derived from norfloxacin (0.99 lg/mL) [34].…”

Section: Antibacterial Activitycontrasting

confidence: 58%

Crystal structures of o , o ′-( N , N ′-dipicolinyldene)diazadiphenyl disulfide and its copper (II) complex: Antioxidant, antibacterial and DNA-binding properties

Moosun

Jhaumeer‐Laulloo

Hosten

et al. 2015

Inorganica Chimica Acta

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Section: Antibacterial Activitycontrasting

confidence: 58%

Crystal structures of o , o ′-( N , N ′-dipicolinyldene)diazadiphenyl disulfide and its copper (II) complex: Antioxidant, antibacterial and DNA-binding properties

Moosun

Jhaumeer‐Laulloo

Hosten

et al. 2015

Inorganica Chimica Acta

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“…Therefore, for improving the quality of life, antioxidant activity is important for preventing the formation of free radicals in human body. According to previous reports in the literature, few metal complexes may able to exhibit the free radical scavenging activity. Hence, it is tried to assess whether the synthesized metal (II) complexes have the free radical scavenging activity.…”

Section: Resultsmentioning

confidence: 86%

Probing of effective pyrazolone based metallonucleases: Molecular docking and in vitro biological critiques

Arunadevi¹,

Paulpandiyan²,

Raman³

2018

Applied Organom Chemis

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Four novel tryptophan based metal (II) complexes of the type [ML (Try)2] were prepared by using pyrazolone derived Schiff base ligand. The proposed structure was confirmed by physicochemical methods which reveal octahedral coordination environment around the metal center. Intercalative binding mode of the complexes with CT DNA was confirmed by electronic absorption titration, viscosity measurements and fluorescence spectroscopy. Efficiency of DNA cleavage ability of the metal complexes was explored by the gel electrophoresis technique. The antimicrobial activities of the metal complexes showed potent biocidal activity. The percentage of free radical scavenging activity shows that the complexes are very reactive towards DPPH. Moreover, their cytotoxicity was tested against the two cancer cell lines (MCF‐7 and HepG2) and one normal cell line (NHDF) respectively. The MTT assay shows that the complexes have the anticancer efficacy. Moreover, the complexes exhibit a limited cytotoxicity effect on normal cell line NHDF. The morphological changes of apoptosis cell death were investigated by using Hoechst 33258 staining method. In addition, the Molecular docking studies was executed to consider the nature of binding and binding affinity of the synthesized compounds with DNA (PDB: 1BNA) and protein (PDB: 3hb5).

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“…4-Aminoantipyrine administration caused a significant decrease in the contracture of myometrium, while the cervix did not reveal significant change [16]. Binding studies of 4-aminoantipyrine with human serum albumin and DNA have already been explored [17,18]. 4-Aminoantipyrine derivatives are well recognized for their clinical and sensor abilities, however no attempt has been made to investigate their anticancer activity against cervical cancer.…”

Section: Introductionmentioning

confidence: 99%

“…This study thus aims at assessing the effectiveness and plausible mode of action of compounds belonging to the class of 4AAP derivatives in HPV positive cervical cancer cells. As an effective receptor to design target based drug design, we selectively chose HPV16 E7 protein [18] and the designing and synthesizing of 4-aminoantipyrine derivatives became one of our major goals.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and spectroscopic characterization of fluorescent 4-aminoantipyrine analogues: Molecular docking and in vitro cytotoxicity studies

Premnath

Selvakumar

Ravichandiran

et al. 2016

Spectrochimica Acta Part A: Molecular and Biomolecular Spectros

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Exploring DNA binding and nucleolytic activity of few 4-aminoantipyrine based amino acid Schiff base complexes: A comparative approach

Cited by 47 publications

References 31 publications

Crystal structures of o , o ′-( N , N ′-dipicolinyldene)diazadiphenyl disulfide and its copper (II) complex: Antioxidant, antibacterial and DNA-binding properties

Crystal structures of o , o ′-( N , N ′-dipicolinyldene)diazadiphenyl disulfide and its copper (II) complex: Antioxidant, antibacterial and DNA-binding properties

Probing of effective pyrazolone based metallonucleases: Molecular docking and in vitro biological critiques

Synthesis and spectroscopic characterization of fluorescent 4-aminoantipyrine analogues: Molecular docking and in vitro cytotoxicity studies

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