Exploring DNA-Binding and anticancer properties of benzoimidazolyl-ferrocene dye

Babgi, Bandar A.; Abdellattif, Magda H.; Hussien, Mostafa A.; Eltayeb, Naser Eltaher

doi:10.1016/j.molstruc.2019.126918

Cited by 15 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…53 Babgi et al reported a benzoimidazolyl ferrocene-containing compound which gives an IC 50 value of 16.5 mM for the lung cancer cell line (A549) and IC 50 value of 842.6 mM for the prostate cancer cell line (PC-3). 54 Toro et al reported that a ferrocenyl fragment with the nitro group at the C-5 position of the benzimidazole ring exhibited better activities than the unsubstituted analogs against chloroquine-resistant W2 strain of P. falciparum with IC 50 ranging from 23.9–48.0 μM. 55 Inside the cell, the ferrocenium conversion of the central iron atom takes place, which exhibits antitumor activity and hence, as the number of ferrocene motifs attached is more than one, it enhances far more the in vitro activities.…”

Section: Resultsmentioning

confidence: 99%

Section: Cell Cytotoxicity Assaymentioning

confidence: 99%

See 1 more Smart Citation

Mono- and di-ferrocene conjugated 5-methyl benzimidazole based multi-channel receptors for cations/anions with their antimicrobial and anticancer studies

Kavitha

Sengottuvelan

2023

New J. Chem.

View full text Add to dashboard Cite

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Cell Cytotoxicity Assaymentioning

confidence: 99%

Mono- and di-ferrocene conjugated 5-methyl benzimidazole based multi-channel receptors for cations/anions with their antimicrobial and anticancer studies

Kavitha

Sengottuvelan

2023

New J. Chem.

View full text Add to dashboard Cite

show abstract

“…are available and used in the treatment of cancer. That's why the hybridization of imidazole and chalcone can give novel antiproliferative agents with multitargeted and synergistic effects [53–55] …”

Section: Imidazole Hybridizes With Other Anticancer Pharmacophoresmentioning

confidence: 99%

Hybridization of Imidazole with Various Heterocycles in Targeting Cancer: A Decade's Work

Teli¹,

Chawla²

2021

ChemistrySelect

View full text Add to dashboard Cite

Cancer is the world‘s biggest global health concern. The prevalence and mortality rates of cancer remain high despite significant progress in cancer therapy. The search for more effective, as well as less toxic treatment methods for cancer, is at the focus of current studies. Approximately 24.6 million people are suffering from cancer across the world as per the world health organization (WHO). In the year 2020, approximately 10 million deaths were reported due to cancer which has emerged as the second leading cause of mortality across the globe. Anticancer medicines have played a pivotal role in the medication of different types of cancers; however, they are associated with several side effects and relevance of drug resistance which evoke an immediate need for designing of new anticancer agents with multitargeted effect. Imidazole is a heterocyclic compound privileged with considerable anticancer activities and some imidazole derivatives have already got approval to treat cancer. Many hybrid molecules are available that play an important role in the treatment of cancer like chalcone, pyrazole, purine, triazine etc., and their pharmacophore provide the anticancer drug with low drug resistance and high efficacy, with low chances of toxicity and side effects. This review provides various approaches for the drug development of new safe and efficient antitumor agents imidazole hybrids with other heterocyclic moieties. An attempt has been made to advancement of the anticancer potential of the derivatives and hybrids of imidazole having intact or condensed imidazole moiety in the last decade along with the structure‐activity relationship studies, and mechanism of action.

show abstract

“…Ferrocene substituted β-azoles cinnamaldehydes and acrylonitriles have important role in medicinal chemistry, cancer therapy and proliferative. [26][27][28][29][30] Herein, we have developed a method for the direct amination of vinylic Csp 2 À N ferrocenyl/phenyl/thiophenyl substituted β-chloro cinnamaldehyde or acrylonitrile under feasible reaction condition (Scheme 2). A highly robust and economical iron catalyst Fe 3 Se 2 (CO) 9 is used for the fabrication of Csp 2 À N bond.…”

Section: Introductionmentioning

confidence: 99%

Novel Ferrocenyl‐azole Derivatives: Synthesis, DFT Calculation and Unlocking the Anticancer Potential

Tomar,

Kumar,

Sharma

et al. 2024

Eur J Org Chem

View full text Add to dashboard Cite

Herein, a series of novel ferrocenyl/phenyl/thiophenyl‐azoles was disclosed by vinylic amination of ferrocenyl/phenyl/thiophenyl substituted β‐chloro cinnamaldehydes and acrylonitriles. A highly economical and robust chalcogen‐stabilized iron selenide carbonyl cluster Fe3Se2(CO)9 worked as an efficient catalyst under aerobic conditions. The amination of ferrocenyl/phenyl/thiophenyl substituted β‐chloro‐vinylic Csp2‐Cl with azole derivatives was fully established and fabrication of the Csp2‐N bond was completely supported by various spectral analysis. Moreover, wide range of substrates with functionally different azoles were investigated for the present reaction and good to excellent transformation was recorded. Some of the selected ferrocenated azole derivatives were screened for anti‐cancer activity against the prostate cancer cells (PC‐3) and found to be highly active at low concentration of 5.77µM with IC50 value. Furthermore, HOMO and LUMO levels and energy gap of some selected compounds were calculated by the density functional theory (DFT).

show abstract

Exploring DNA-Binding and anticancer properties of benzoimidazolyl-ferrocene dye

Cited by 15 publications

References 30 publications

Mono- and di-ferrocene conjugated 5-methyl benzimidazole based multi-channel receptors for cations/anions with their antimicrobial and anticancer studies

Mono- and di-ferrocene conjugated 5-methyl benzimidazole based multi-channel receptors for cations/anions with their antimicrobial and anticancer studies

Hybridization of Imidazole with Various Heterocycles in Targeting Cancer: A Decade's Work

Novel Ferrocenyl‐azole Derivatives: Synthesis, DFT Calculation and Unlocking the Anticancer Potential

Contact Info

Product

Resources

About