Exploring Covalent Bond Formation at Tyr‐82 for Inhibition of Ral GTPase Activation
Alexander D. Landgraf,
I‐Ju Yeh,
Mona K. Ghozayel
et al.
Abstract:Ral RAS GTPases are directly activated by KRAS through a trimeric complex with a guanine exchange factor. Ral is considered undruggable and lacks an accessible cysteine for covalent drug development. Previously we had reported an aryl sulfonyl fluoride fragment that formed a covalent bond at Tyr‐82 on Ral and created a deep and well‐defined pocket. Here, we explore this pocket further through design and synthesis of several fragment derivatives. The fragment core is modified by introducing tetrahydronaphthalen… Show more
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