Exploring conditions that make cortical bone geometry optimal for physiological loading

Sen, Chander; Prasad, Jitendra

doi:10.1007/s10237-019-01147-z

Cited by 5 publications

(1 citation statement)

References 61 publications

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“…The rationale of sample site choice specifically resides in determining whether there exists a relationship between lacunar shape and density in presence of different load distributions. Indeed, while at the meso -scale it is widely recognized [46] , [47] that trabeculae are arranged in the three-dimensional space as a response to the external loading scenario (Wolff’s law), the micro-scale architectural adaptation to mechanical loadings is still a black box.…”

Section: Methodsmentioning

confidence: 99%

Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing

Buccino

Zagra²,

Longo

et al. 2023

Materials & Design

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Section: Methodsmentioning

confidence: 99%

Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing

Buccino

Zagra²,

Longo

et al. 2023

Materials & Design

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Bone Anatomy and Healing Process of a Fracture

Longo

Stelitano

Candela

et al. 2021

Joint Function Preservation

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A Simplistic Approach to Bone Healing Simulation

Sen

Prasad

2022

Crit Rev Biomed Eng

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A simple computational approach to simulation of healing in long bone fractures is presented. In particular, an algorithm that could simulate the formation, maturation, and resorption of fracture callus is developed and validated. The simplicity of the approach lies in the fact that the algorithm uses only the applied load and a single constraint parameter for the entire simulation. The work hypothesizes bone healing as a comprehensive energy minimization process where mechanical stimulation is proposed as the primary precursor for the beginning of different stages (i.e., callus formation, mineralization, and resorption). As such, the hypothesis is derived from the second law of thermodynamics which states that the energy of a closed system should be minimum at equilibrium. Alternatively, each stage of healing bone healing may be termed a state of homeostasis. The validation is done through a multi-material, time-based simulation of bone healing in a damaged tibia. The simulation uses a cross-section-based finite element model and an advanced version of an already validated structural optimization algorithm. The optimization objective is to minimize overall strain energy for the entire process, subject to a polar first moment of mass constraint. The simulation results show different stages of healing, where the algorithm generates a callus geometry similar to those observed experimentally. Eventually, a geometry similar to that in an intact cross-section is achieved by resorption of the callus from the unwanted sites.

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Exploring conditions that make cortical bone geometry optimal for physiological loading

Cited by 5 publications

References 61 publications

Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing

Osteoporosis and Covid-19: Detected similarities in bone lacunar-level alterations via combined AI and advanced synchrotron testing

Bone Anatomy and Healing Process of a Fracture

A Simplistic Approach to Bone Healing Simulation

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