Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index

Agrawal, Rupesh; Ding, Jianbin; Sen, Parveen; Rousselot, Andrés; Chan, Amy; Nivison‐Smith, Lisa; Wei, Xin; Mahajan, Sarakshi; Ramasamy, Kim; Mishra, Chitaranjan; Agarwal, Manisha; Suh, Min Hee; Luthra, Saurabh; Munk, Marion R.; Cheung, Carol Y.; Gupta, Vishali

doi:10.1016/j.preteyeres.2020.100829

Cited by 165 publications

(196 citation statements)

References 160 publications

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“…The former reflects the circulatory volume in Haller's and Sattler's layers, and the latter reflect areas in the choriocapillaris with low perfusion or without perfusion, thus outlining the global choroidal circulation. These methods have shown good repeatability and reproducibility in studies by others, 32,33,42,44,45 as well as by us in the present work.…”

Section: Physiological Meaning Of the Choroidal Parameters In Ss-oct/supporting

confidence: 76%

Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA

Zhang

Shen

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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Section: Physiological Meaning Of the Choroidal Parameters In Ss-oct/supporting

confidence: 76%

Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA

Zhang

Shen

et al. 2021

Invest. Ophthalmol. Vis. Sci.

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“…Only if the CR does not exceed the effect size can measurement noise be neglected as a source of error. Typical reported differences between healthy and disease conditions are around 2% to 6% for CVI (review: Agrawal et al 11 ). For ChT, the effect size is highly dependent on the condition studied.…”

Section: Discussionmentioning

confidence: 99%

“…The higher the CVI, the more vascular tissue compared with stromal tissue is present in the choroid. 11 CVI was previously investigated in a healthy study population, 12 as well as in ocular pathologies, such as diabetic retinopathy, 13 central serous chorioretinopathy, 14 age-related macula degeneration, 15 panuveitis, 16 and retinitis pigmentosa. 17 While there are only a few studies existent, they report only vague and somewhat inconsistent association between choroidal vascularity and myopia.…”

Section: Introductionmentioning

confidence: 99%

“…After segmentation of the choroidal area, the hyporeflective blood vessel lumina are distinguished from the hyperreflective stromal tissue. The reliability of the results from graphical analysis strongly depends on the OCT technology (scan depth, scan resolution, and image contrast) 11 , 22 but also on subject factors (absolute choroidal thickness and the pigmentation of the retinal pigment epithelium). 23 , 24 Therefore, these parameters influence the repeatability of ChT and CVI measurements.…”

Section: Introductionmentioning

confidence: 99%

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Choroidal Biomarkers: A Repeatability and Topographical Comparison of Choroidal Thickness and Choroidal Vascularity Index in Healthy Eyes

Breher

Terry

Bower

et al. 2020

Trans. Vis. Sci. Tech.

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Purpose Choroidal thickness (ChT) and choroidal vascularity index (CVI) represent two important metrics in health-, disease-, and myopia-related studies. Wide-field swept-source optical coherence tomography (OCT) provides improved and extended imaging and extraction of choroidal variables. This study characterizes the topography and repeatability of these parameters in healthy eyes. Methods Swept-source OCT volume scans were obtained on 14 young adult patients on three separate days. ChT and CVI were automatically corrected for image magnification and extracted for different enface regions within an extended ETDRS grid of 10 mm diameter. Topographical distribution, correlation to ocular length, and intersession repeatability of both choroidal parameters were assessed. Results CVI showed little fluctuation between subfields, unlike ChT, which demonstrated thinning toward the peripheral choroid (coefficients of variation 5.92 vs. 0.89). ChT showed a consistent negative correlation with axial length (ρ = −0.05 to −0.61), although this was only statistically significant in the inner superior subfield ( P = 0.02). There was no consistent or significant relationship between CVI and axial length or between CVI and ChT. The repeatability of CVI measurements (3.90%–5.51%) was more consistent between scan regions than ChT measurements (10.37–20.33 µm). Conclusions CVI values were consistent across the central 10 mm of the retina, while ChT reduced with eccentricity. The repeatability of both parameters is similar to the effect size reported in many studies using the choroid as a biomarker, which should be considered in the interpretation of findings. Translational Relevance This study provided normative as well as metrological information for the clinical interpretation of ChT and CVI in health and disease.

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“…To date, there has been limited investigation of the choroid in relation to the presence of CSs in patients with CHM. The choroidal vascularity index (CVI) provides the capability to calculate quantitative parameters of the choroid and stratify the stromal and vascular components [9,10].…”

Section: Introductionmentioning

confidence: 99%

Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces

et al. 2021

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Cystoid spaces (CSs) are a common retinal finding in choroideremia (CHM) patients. The aim of this study was to analyze the vascular features of the choroid associated with the presence of CSs in patients with confirmed genetic diagnosis of CHM. A total of 33 patients (33 eyes) were enrolled in this retrospective cross-sectional study and divided into two groups based on the presence (17 eyes) or absence (16 eyes) of CSs. Choroidal features were evaluated on spectral-domain optical coherence tomography including subfoveal choroidal thickness (CT), total choroidal area (TCA), luminal choroidal area (LCA), and stromal choroidal area (SCA). The choroidal vascularity index (CVI) was then calculated in all study eyes. All structural choroidal parameters were calculated both on the entire length of the B-scan and in the central subfoveal 1500 μm. The average age was 37.3 ± 11.6 and 31.4 ± 16.7 years (p = 0.25) and mean logMAR best-corrected visual acuity was 0.11 ± 0.20 and 0.20 ± 0.57 (p = 0.54) in the CHM groups with and without CSs, respectively. There were no significant differences in subfoveal CT, and TCA, LCA, SCA, and CVI evaluated on either the entire scan or in the central 1500 μm (all p > 0.05). All choroidal vasculature parameters exhibited no significant differences between CHM eyes with and without CSs. Our results suggest that the choroid may not be involved in the development of CSs in patients with CHM.

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Exploring choroidal angioarchitecture in health and disease using choroidal vascularity index

Cited by 165 publications

References 160 publications

Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA

Assessment of Choroidal Vascularity and Choriocapillaris Blood Perfusion in Anisomyopic Adults by SS-OCT/OCTA

Choroidal Biomarkers: A Repeatability and Topographical Comparison of Choroidal Thickness and Choroidal Vascularity Index in Healthy Eyes

Choroidal Vascularity Features in Patients with Choroideremia and Cystoid Spaces

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