Exploring bioactivity potential of polyphenolic water-soluble lignin derivative

Fedoros, Elena I.; Балдуева, Ирина; Perminova, Irina V.; Badun, G. A.; Chernysheva, Maria G.; Grozdova, Irina D.; Melik-Nubarov, Nickolay S.; Данилова, Анна; Nekhaeva, Tatyana; Kuznetsova, A. I.; Emelyanova, N.V.; Ryakhovskiy, Alexey A; Pigarev, Sergey E.; Семенов, А. Л.; Tyndyk, Margarita L.; Губарева, Е. А.; Panchenko, Andrey; Быков, В. Н.; Anisimov, Vladimir N.

doi:10.1016/j.envres.2020.110049

Cited by 10 publications

(5 citation statements)

References 48 publications

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“…The genoprotective activity of BP-C2 established in our experiments can apparently be attributed to its polyphenolic backbone (BP-Cx-1), which contains many biologically active compounds (i.e., flavonoids, sapogenins, phenanthrenes) [17] . The biological activity of the BP-C2 observed in vivo is considered to be associated with the ability of its organic core to bind to glucocorticoid receptor and serotonin receptor 5-HT1 [16] . As the exposure of test subjects to genotoxicants was relatively short in our experiments (several hours), anti-oxidant and not the anti-inflammatory activity was apparently the leading mechanism of antigenotoxic activity of BP-C2.…”

Section: Discussionmentioning

confidence: 99%

Antigenotoxic and antimutagenic effects of lignin derivative BP-C2 against dioxidine and cyclophosphamide in vivo in murine cells

et al. 2022

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Section: Discussionmentioning

confidence: 99%

Antigenotoxic and antimutagenic effects of lignin derivative BP-C2 against dioxidine and cyclophosphamide in vivo in murine cells

et al. 2022

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“…Low microbiological activity, a relatively high level of hydromorphism in Cryosols and the predominance of moss and lichens in the plant composition lead to the accumulation of aliphatic fragments. In the studied soils, the vegetation cover was dominated by vascular plants, in which up to 30% of lignin-containing fragments were accumulated [59]. Under conditions of demitylation, during the decomposition of lignin, the HA structure accumulates a carboxyl group, which leads to the stabilization of organic matter [8,9,21,23,30,32,34,52,58].…”

Section: The Stabilization Of Organic Matter Based On 13 C Nmr Spectroscopymentioning

confidence: 99%

“…Lignin makes the greatest contribution to the aromaticity of molecules [59]. This component is relatively resistant to biodegradation.…”

Section: The Stabilization Of Organic Matter Based On 13 C Nmr Spectroscopymentioning

confidence: 99%

Assessments of Organic Carbon Stabilization Using the Spectroscopic Characteristics of Humic Acids Separated from Soils of the Lena River Delta

Polyakov

Abakumov

2021

Separations

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In the Arctic zone, where up to 1024 × 1013 kg of organic matter is stored in permafrost-affected soils, soil organic matter consists of about 50% humic substances. Based on the analysis of the molecular composition of humic acids, we assessed the processes of accumulation of the key structural fragments, their transformations and the stabilization rates of carbon pools in soils in general. The landscape of the Lena River delta is the largest storage of stabilized organic matter in the Arctic. There is active accumulation and deposition of a significant amount of soil organic carbon from terrestrial ecosystems in a permafrost state. Under ongoing climate change, carbon emission fluxes into the atmosphere are estimated to be higher than the sequestration and storing of carbon compounds. Thus, investigation of soil organic matter stabilization mechanisms and rates is quite an urgent topic regarding polar soils. For study of molecular elemental composition, humic acids were separated from the soils of the Lena River delta. Key structural fragments of humic matter were identified and quantified by CP/MAS 13C NMR spectroscopy: carboxyl (–COOR); carbonyl (–C=O); CH3–; CH2–; CH-aliphatic; –C-OR alcohols, esters and carbohydrates; and the phenolic (Ar-OH), quinone (Ar = O) and aromatic (Ar–) groups as benchmark Cryosols of the Lena delta river terrestrial ecosystem. Under the conditions of thermodynamic evolutionary selection, during the change between the dry and wet seasons, up to 41% of aromatic and carboxyl fragments accumulated in humic acids. Data obtained showed that three main groups of carbon played the most important role in soil organic matter stabilization, namely C, H-alkyls ((CH2)n/CH/C and CH3), aromatic compounds (C-C/C-H, C-O) and an OCH group (OCH/OCq). The variations of these carbon species’ content in separated humics, with special reference to soil–permafrost organic profiles’ recalcitrance in the current environment, is discussed.

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“…It has been shown that polyphenols can act as traps for free radicals [8,9] and therefore prevent oxidative stress [10]. In addition to that, they possess an anti-inflammatory effect, which is manifested in the suppression of the synthesis of cytokines and interleukins of the pro-inflammatory spectrum [11]. Depending on the origin, natural mixtures can exhibit hepatoprotective properties, including the aforementioned prevention of oxidative stress (e.g., silibinin, catergen), stimulation of liver parenchyma regeneration [12], and alleviation of NADFL biochemical symptoms [13,14].…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Activity of Lignin-Derived Polyphenols Dereplicated Using High-Resolution Mass Spectrometry, In Vivo Experiments, and Deep Learning

Orlov

Semenov

Rukhovich

et al. 2022

IJMS

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Chronic liver diseases affect more than 1 billion people worldwide and represent one of the main public health issues. Nonalcoholic fatty liver disease (NAFLD) accounts for the majority of mortal cases, while there is no currently approved therapeutics for its treatment. One of the prospective approaches to NAFLD therapy is to use a mixture of natural compounds. They showed effectiveness in alleviating NAFLD-related conditions including steatosis, fibrosis, etc. However, understanding the mechanism of action of such mixtures is important for their rational application. In this work, we propose a new dereplication workflow for deciphering the mechanism of action of the lignin-derived natural compound mixture. The workflow combines the analysis of molecular components with high-resolution mass spectrometry, selective chemical tagging and deuterium labeling, liver tissue penetration examination, assessment of biological activity in vitro, and computational chemistry tools used to generate putative structural candidates. Molecular docking was used to propose the potential mechanism of action of these structures, which was assessed by a proteomic experiment.

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Exploring bioactivity potential of polyphenolic water-soluble lignin derivative

Cited by 10 publications

References 48 publications

Antigenotoxic and antimutagenic effects of lignin derivative BP-C2 against dioxidine and cyclophosphamide in vivo in murine cells

Antigenotoxic and antimutagenic effects of lignin derivative BP-C2 against dioxidine and cyclophosphamide in vivo in murine cells

Assessments of Organic Carbon Stabilization Using the Spectroscopic Characteristics of Humic Acids Separated from Soils of the Lena River Delta

Hepatoprotective Activity of Lignin-Derived Polyphenols Dereplicated Using High-Resolution Mass Spectrometry, In Vivo Experiments, and Deep Learning

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