Exploring bioactive peptides as potential therapeutic and biotechnology treasures: A contemporary perspective

Patil, Prasanna J.; Sutar, Shubham; Usman, Muhammad; Patil, Devashree N.; Dhanavade, Maruti J.; Shehzad, Qayyum; Mehmood, Arshad; Shah, Haroon; Chen, Teng; Zhang, Chengnan; Li, Xiuting

doi:10.1016/j.lfs.2022.120637

Cited by 7 publications

(19 citation statements)

References 121 publications

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“…This means that regulatory affairs professionals will need to be familiar with the regulatory requirements of multiple jurisdictions. [24] They will also need to be able to work effectively with cross-functional teams to ensure that products are compliant with all applicable regulations.…”

Section: The Role Of Regulatory Bodies In Novel Drug Delivery Systems...mentioning

confidence: 99%

Role of regulatory affairs in nanoparticles formulation

Singh

2023

Pharmaspire

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Nanoparticles are small particles that have a wide range of potential applications, including drug delivery, imaging, and diagnostics. However, the safety and efficacy of nanoparticles are still not fully understood, and there are concerns about their potential to cause toxicity. Regulatory affairs professionals play a key role in ensuring the safety and efficacy of nanoparticles by interpreting and applying regulatory guidelines, conducting safety assessments, and preparing regulatory submissions. They also communicate with regulatory agencies throughout the development and commercialization of nanoparticle products. By carefully performing these tasks, regulatory affairs professionals can help to bring these innovative products to market while protecting the public health. The role of regulatory affairs in nanoparticles formulation is complex and challenging, but it is essential to ensure the safety and efficacy of these innovative products. By carefully performing their duties, regulatory affairs professionals can help to bring these products to market and improve the lives of millions of people.

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Section: The Role Of Regulatory Bodies In Novel Drug Delivery Systems...mentioning

confidence: 99%

Role of regulatory affairs in nanoparticles formulation

Singh

2023

Pharmaspire

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“…The therapeutic activity of food-derived bioactive proteins and peptides -such as from medicinal plants -is attracting increasing attention in the research community 39 . Bioactive peptides offer promising potential as antiviral drugs, and therapeutic peptides are an exciting alternative to be developed into anti-Dengue virus drugs due to their safety and diverse biological and chemical properties 50 . In addition, many potential compounds were identi ed from C. racemosa metabolites pro les, such as choline 51 , betaine 52 , oleamide 53 , hexadecanamide 54 , palmitoleic acid 55 , and α-eleostearic acid 56 .…”

Section: Cytotoxicity Evaluation Of C Racemosa Using Mtt Assaymentioning

confidence: 99%

“…Fifty (50) μl of extract samples (Maceration; Soxhlet Method) were diluted using 96% ethanol up to a nal volume of 1,500 μl. The solutions were vortexed at 2,000 rpm for 2 minutes and then span-down at 6,000 rpm for 2 minutes.…”

Section: Analysis Of the Maceration And Soxhlet Samples By Hplc-esi-h...mentioning

confidence: 99%

Metabolomic Profiling, In Vitro Antioxidant and Cytotoxicity Properties of Caulerpa racemosa : Functional Food of the Future from Algae

Mayulu

Hardinsyah

Yusuf

et al. 2022

Preprint

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Marine macroalgae are nutraceuticals rich in nutritional profile and secondary bioactive metabolites. However, they have varied nutritional and biochemical qualities due to a variety of reasons. This study aimed to determine the phytochemical profile and biological activities of Caulerpa racemosa, edible green algae also known as Sea grapes. The study successfully identified secondary metabolites through metabolomic profiling untargeted by LC-HRMS as well as a bioactive peptide. In addition, antioxidant activity and cytotoxicity of extracts and compounds were determined. A total of 103 metabolites were identified in C. racemosa extract obtained by the maceration, while 48 were detected in the soxhlet extract. A peptide with the sequence ELWKTF (Glu-Leu-Trp-Lys-Thr-Phe; C41H58N8O) and its abundance was identified in the α-chymotrypsin hydrolysate of C. racemosa. In the antioxidant activity test, Soxhletated-extract (ES) and purified fraction 1 (PF1) had half-maximal effective concentration (EC50) < EC50 of control/GSH (DPPH inhibition) and PF1 had EC50 < EC50 of control/Trolox (ABTS inhibition). The cytotoxicity results showed that macerated-extract (EM), ES, and PF1 as antioxidant agents in the observed EC50 were safe. In general, C. racemosa contains antioxidant nutrients, metabolites, and bioactive peptides, a factor that makes it a promising functional food and pharmaceutical.

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“…In recent years, independent research groups have demonstrated the potential use of peptides as anti-inflammatory agents due to their ability to both compete with proinflammatory molecules for specific binding sites [24][25][26], and penetrate the cell and trigger or inhibit signal transmission [27,28]. Using phage display [29], we discovered a 9-aminoacid cyclic peptide targeting α v β 3 integrin-mediated signaling and named it ALOS4.…”

Section: Introductionmentioning

confidence: 99%

Targeted Modulation of Interferon Response-Related Genes with IFN-Alpha/Lambda Inhibition

Sur

Leonova

Levi

et al. 2022

IJMS

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Interferon (IFN) signaling resulting from external or internal inflammatory processes initiates the rapid release of cytokines and chemokines to target viral or bacterial invasion, as well as cancer and other diseases. Prolonged exposure to IFNs, or the overexpression of other cytokines, leads to immune exhaustion, enhancing inflammation and leading to the persistence of infection and promotion of disease. Hence, to control and stabilize an excessive immune response, approaches for the management of inflammation are required. The potential use of peptides as anti-inflammatory agents has been previously demonstrated. Our team discovered, and previously published, a 9-amino-acid cyclic peptide named ALOS4 which exhibits anti-cancer properties in vivo and in vitro. We suggested that the anti-cancer effect of ALOS4 arises from interaction with the immune system, possibly through the modulation of inflammatory processes. Here, we show that treatment with ALOS4 decreases basal cytokine levels in mice with chronic inflammation and prolongs the lifespan of mice with acute systemic inflammation induced by irradiation. We also show that pretreatment with ALOS4 reduces the expression of IFN alpha, IFN lambda, and selected interferon-response genes triggered by polyinosinic-polycytidylic acid (Poly I:C), a synthetic analog of viral double-stranded RNA, while upregulating the expression of other genes with antiviral activity. Hence, we conclude that ALOS4 does not prevent IFN signaling, but rather supports the antiviral response by upregulating the expression of interferon-response genes in an interferon-independent manner.

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Exploring bioactive peptides as potential therapeutic and biotechnology treasures: A contemporary perspective

Cited by 7 publications

References 121 publications

Role of regulatory affairs in nanoparticles formulation

Role of regulatory affairs in nanoparticles formulation

Metabolomic Profiling, In Vitro Antioxidant and Cytotoxicity Properties of Caulerpa racemosa : Functional Food of the Future from Algae

Targeted Modulation of Interferon Response-Related Genes with IFN-Alpha/Lambda Inhibition

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