Exploring and Adapting the Molecular Selectivity of Artificial Metalloenzymes

Vong, Kenward; Nasibullin, Igor; Tanaka, Katsunori

doi:10.1246/bcsj.20200316

Cited by 15 publications

(6 citation statements)

References 220 publications

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“…[6][7][8][9] Together, these approaches have greatly expanded the scope of chemical transformations that haem proteins can mediate. [10][11][12][13] In addition to artificial metalloenzymes, the incorporation of non-iron metalloporphyrins in haem proteins has enabled the development of designer proteins as optical oxygen sensors, 14,15 MRI contrast agents, 16,17 spectroscopic probes, [18][19][20] and tools to interrogate protein function. [21][22][23] A less explored approach is substitution of the porphyrin cofactor with an alternative tetrapyrrole macrocycle or a related ligand.…”

Section: Introductionmentioning

confidence: 99%

Corrole–protein interactions in H-NOX and HasA

et al. 2022

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Section: Introductionmentioning

confidence: 99%

Corrole–protein interactions in H-NOX and HasA

et al. 2022

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“…This biocompatible nanoarchitecture on proteins to produce glycosylated artificial metalloenzymes requires non-natural chemical reactions within living biological systems. Additional functions of molecular selectivity to artificial metalloenzymes [ 170 ] are useful in various application areas such as diagnostics, drug therapy, and pharmaceutical synthesis.…”

Section: Nanoarchitectonics With Proteinsmentioning

confidence: 99%

Biomimetic and Biological Nanoarchitectonics

Ariga

2022

IJMS

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A post-nanotechnology concept has been assigned to an emerging concept, nanoarchitectonics. Nanoarchitectonics aims to establish a discipline in which functional materials are fabricated from nano-scale components such as atoms, molecules, and nanomaterials using various techniques. Nanoarchitectonics opens ways to form a more unified paradigm by integrating nanotechnology with organic chemistry, supramolecular chemistry, material chemistry, microfabrication technology, and biotechnology. On the other hand, biological systems consist of rational organization of constituent molecules. Their structures have highly asymmetric and hierarchical features that allow for chained functional coordination, signal amplification, and vector-like energy and signal flow. The process of nanoarchitectonics is based on the premise of combining several different processes, which makes it easier to obtain a hierarchical structure. Therefore, nanoarchitectonics is a more suitable methodology for creating highly functional systems based on structural asymmetry and hierarchy like biosystems. The creation of functional materials by nanoarchitectonics is somewhat similar to the creation of functional systems in biological systems. It can be said that the goal of nanoarchitectonics is to create highly functional systems similar to those found in biological systems. This review article summarizes the synthesis of biomimetic and biological molecules and their functional structure formation from various viewpoints, from the molecular level to the cellular level. Several recent examples are arranged and categorized to illustrate such a trend with sections of (i) synthetic nanoarchitectonics for bio-related units, (ii) self-assembly nanoarchitectonics with bio-related units, (iii) nanoarchitectonics with nucleic acids, (iv) nanoarchitectonics with peptides, (v) nanoarchitectonics with proteins, and (vi) bio-related nanoarchitectonics in conjugation with materials.

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“…This has given rise to the term artificial metalloenzymes (ArM), which can be defined as biocatalysts that have been unnaturally altered to be used for new-to-nature reactions within living systems. [77][78][79] In literature, there are currently two main streams of ArMbased research. The first is to take existing metalloproteins and manipulate its structure to control the environment directly surrounding the metal, thereby influencing factors like substrate specificity and stereoselectivity.…”

Section: Metalloproteinsmentioning

confidence: 99%

“…By mimicking this process, researchers should be able to adapt several different types of abiotic metals as functional metalloenzymes. This has given rise to the term artificial metalloenzymes (ArM), which can be defined as biocatalysts that have been unnaturally altered to be used for new‐to‐nature reactions within living systems [77–79] …”

Section: Metalloproteinsmentioning

confidence: 99%

Transition Metal Scaffolds Used To Bring New‐to‐Nature Reactions into Biological Systems

2022

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As a means to develop new tools to manipulate biological systems, transition metals have been looked upon as an area of high potential due to the bioorthogonality of new-to-nature reactions. To facilitate their incorporation into complex biological systems, researchers have mainly focused on the development of metal catalyst complexes, protein scaffolds, and nanocarriers to protect and preserve the biocatalytic activity of transition metals. The intent of this review is to summarize these structural scaffolds, which has steadily allowed researchers to push transition metal usage not previously thought possible within bacteria, mammalian cells, and higherlevel organisms.

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Exploring and Adapting the Molecular Selectivity of Artificial Metalloenzymes

Cited by 15 publications

References 220 publications

Corrole–protein interactions in H-NOX and HasA

Corrole–protein interactions in H-NOX and HasA

Biomimetic and Biological Nanoarchitectonics

Transition Metal Scaffolds Used To Bring New‐to‐Nature Reactions into Biological Systems

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