Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood

Xiao, Ting; Zhang, Sheng; Lee, Lue-En; Chao, Herta H.; Dyck, Christopher van; Li, Chiang‐Shan R.

doi:10.3389/fnagi.2018.00209

Cited by 24 publications

(17 citation statements)

References 122 publications

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“…Secondly, for all participants, the left AMYG was positively correlated with the bilateral hippocampus, parahippocampal gyri and ventral medial prefrontal cortex, which are important components of limbic network. Such connections resemble those found in normal population 46,50–52 , implying the role of left AMYG in emotional and central autonomic processing through interactions with subcortical regions and prefrontal cortex 6,7 as proposed by the neurovisceral integration model 16–18 . In addition, the strength of the connectivity between the left AMYG and the right putamen increased as a function of accumulated baseball-playing experience.…”

Section: Discussionsupporting

confidence: 66%

“…AB participants were younger than IB participants ( p < 0.001, Bonferroni correction) and HC participants ( p < 0.001, Bonferroni correction). To regress the effect of age difference, we considered age as a covariate of no interest in the imaging data analysis, as suggested in previous studies 45,46 . No significant differences in body mass index ( p = 0.172) and Edinburgh handedness inventory ( p = 0.347) were found among the three groups.…”

Section: Resultsmentioning

confidence: 99%

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Altered Central Autonomic Network in Baseball Players: A Resting-state fMRI Study

Sie

Chen

Chang

et al. 2019

Sci Rep

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The physiological adaptive regulation of healthy population with a high fitness level is associated with enhanced cognitive control in brain. This study further investigated the effects of different levels of sporting experience on intrinsic brain networks involved in central autonomic processing using resting-state functional magnetic resonance imaging. We explored functional connectivity of four core regions within central autonomic network (CAN), namely posterior midcingulate cortex (pMCC), left amygdala (AMYG), and right anterior (aINS) and left posterior insular cortices, in advanced and intermediate baseball players, and compared their strength of connectivity with individuals without baseball-playing experience. Functional connectivity maps across three groups confirmed a close relationship between CAN and large-scale brain networks in sensory, motor and cognitive domains. Crucially, both advanced and intermediate batters demonstrated enhanced connectivity between pMCC and sensorimotor network, between right aINS and dorsal anterior cingulate cortex, and between left AMYG and right putamen, than controls. These results reflected a stronger interregional coupling in sensorimotor and cognitive control, and in motor skill consolidation. In conclusion, we provided evidence that different levels of sporting experience could reorganize/enhance intrinsic functional connectivity for central autonomic processing.

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Section: Discussionsupporting

confidence: 66%

Section: Resultsmentioning

confidence: 99%

Altered Central Autonomic Network in Baseball Players: A Resting-state fMRI Study

Sie

Chen

Chang

et al. 2019

Sci Rep

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“…These findings are in concurrence with the observations made by the previous studies ((Wang et al, 2015b); (Cao et al, 2014); (Sakaki et al, 2016); (Xiao et al, 2018)) that in contrast to the DMN and CEN, within network connectivity is preserved or increased in SN with aging. Our result suggests that this preservation of causal connectivity patterns within SN may be crucial for aging and could be driven by thalamus.…”

Section: Discussionsupporting

confidence: 93%

Reconfiguration of directed functional connectivity among triple networks with aging: Considering the role of thalamo-cortical interactions

Das

Singh

Uddin

et al. 2019

Preprint

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9The human brain undergoes both significant structural and functional changes across the 10 lifespan. It is important to understand the underlying causal relationship of the emerging dy-11 namical changes in functional connectivity with age. On average, functional connectivity 12 within resting-state networks weakens in magnitude while connections between resting-state 13 networks tend to increase with age. Further, few recent studies show that effective connectivity 14 within and between large scale resting-state functional networks changes over the healthy 15 lifespan. Motivated by these findings we move one step forward to investigate the effect of the 16 thalamus in the context of healthy aging. Using directed connectivity and weighted net causal 17 outflow measures on resting-state fMRI data, we examine the age-related changes in both cor-18 tical and thalamocortical causal interactions within and between resting-state networks. The 19 three of core neurocognitive networks DMN, SN, CEN networks are identified independently 20 by carrying out ICA as well as spatially matching of hub regions with the important RSNs 21 previously reported in the literature. Thereafter, multivariate GCA was performed to test for 22 23 are two major findings, firstly, we observe that within network causal connections become 24 progressively weaker with age, however, between network causal connections are getting 25 stronger with age among core neurocognitive networks, primarily a reflection of within and 26 between network resting-state functional connectivity. Secondly, significant modifications 27 were found in causal connections and net causal outflows in the presence of thalamus. Finally, 28we found that the thalamus plays a crucial role as an exogenous drive in the reorganization of 29 within network causal outflow, while Salience network plays a critical role in mediating be-30 tween network causal outflow with age among cortical networks. Our findings with the 31 weighted causal outflow measures strengthen the hypothesis that balancing within and between 32 network connectivity is perhaps critical for the preservation of cognitive functions with aging. 33 34 35

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“…For example, older adult brains show decreased gray matter volume within hubs of the salience network (e.g., insula, dorsal anterior cingulate cortex or dACC) relative to younger adults (He et al, 2014;Sun et al, 2016) as well as altered functional connectivity between hubs within the salience network and between the salience network and other functional networks. Yet some findings are inconsistent: some studies show either preservation or increased age-related salience network connectivity (Cao et al, 2014;Xiao et al, 2018) whereas others show age-related declines in connectivity (E. A. Allen et al, 2011;He et al, 2013He et al, , 2014Onoda et al, 2012;Roski et al, 2013).…”

Section: Hypotheses About Age-related Nervous System Shifts During Afmentioning

confidence: 99%

Affect in the Aging Brain: A Neuroimaging Meta-Analysis of Older Vs. Younger Adult Affective Experience and Perception

et al. 2020

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We report the first functional neuroimaging meta-analysis on age-related differences in adult neural activity during affect. We identified and coded experimental contrasts from 27 studies (published 1997-2018) with 490 older adults (55-87 years, M age = 69 years) and 470 younger adults (18-39 years, M age = 24 years). Using multilevel kernel density analysis, we assessed functional brain activation contrasts for older vs. younger adult affect across in-scanner tasks (i.e., affect induction and perception). Relative to older adults, younger adults showed more reliable activation in subcortical structures (e.g., amygdala, thalamus, caudate) and in relatively more posterior aspects of specific brain structures (e.g., posterior insula, mid-and posterior cingulate). In contrast, older adults exhibited more reliable activation in the prefrontal cortex and more anterior aspects of specific brain structures (e.g., anterior insula, anterior cingulate). Meta-analytic coactivation network analyses further revealed that in younger adults, the amygdala and mid-cingulate were more central, locally efficient network nodes, whereas in older adults, regions in the superior and medial prefrontal cortex were more central, locally efficient network nodes. Collectively, these findings help characterize age differences in the brain basis of affect and provide insights for future investigations into the neural mechanisms underlying affective aging.

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Exploring Age-Related Changes in Resting State Functional Connectivity of the Amygdala: From Young to Middle Adulthood

Cited by 24 publications

References 122 publications

Altered Central Autonomic Network in Baseball Players: A Resting-state fMRI Study

Altered Central Autonomic Network in Baseball Players: A Resting-state fMRI Study

Reconfiguration of directed functional connectivity among triple networks with aging: Considering the role of thalamo-cortical interactions

Affect in the Aging Brain: A Neuroimaging Meta-Analysis of Older Vs. Younger Adult Affective Experience and Perception

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