Exploratory Study of the Effects of Single Doses of Isomazole on Hemodynamics and Heart Rate Variability Parameters in Chronic Heart Failure

Calcium‐Sensitizing Drugs: Positive Inotropy by Enhanced Sensitivity of the Contractile Apparatus to Calcium

“…The analog compound isomazole has been tested in phase I11 clinical trials (51), but only limited clinical data are yet available. In a recent study, Tuininga et al (114) evaluated the effect of single doses of sulmazole on hemodynamics and heart rate vanability in heart failure patients. Mean arterial pulmonary pressure and pulmonary wedge pressure decreased after 10 and 20 mg doses, whereas cardiac output increased only after the higher dose.…”