Exploratory eye movements in schizophrenia

Tonoya, Yasuhiro; Matsui, Mié; Kurachi, Masayoshi; Kurokawa, Kenzo; Sumiyoshi, Tomiki

doi:10.1007/s00406-002-0390-5

Cited by 18 publications

(1 citation statement)

References 23 publications

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“…This result can be related to studies on attentional control and cognitive flexibility in schizophrenia (Granholm et al, 1999; Ducato et al, 2008a,b). Indeed, patients with schizophrenia are able to normalize their pattern of visual exploration when they are actively involved in more demanding tasks (Kurachi et al, 1994; Tonoya et al, 2002; Delerue et al, 2010; Delerue and Boucart, 2012, 2013). …”

Section: Discussionmentioning

confidence: 99%

Imagined motor action and eye movements in schizophrenia

Delerue

Boucart

2013

Front. Psychol.

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Visual exploration and planning of actions are reported to be abnormal in schizophrenia. Most of the studies monitoring eye movements in patients with schizophrenia have been performed under free-viewing condition. The present study was designed to assess whether mentally performing an action modulates the visuomotor behavior in patients with schizophrenia and in healthy controls. Visual scan paths were monitored in eighteen patients with schizophrenia and in eighteen healthy controls. Participants performed two tasks in which they were asked either to (1) look at a scene on a computer screen (free viewing), or (2) picture themselves making a sandwich in front of a computer screen (active viewing). The scenes contained both task-relevant and task-irrelevant objects. Temporal and spatial characteristics of scan paths were compared for each group and each task. The results indicate that patients with schizophrenia exhibited longer fixation durations, and fewer fixations, than healthy controls in the free viewing condition. The patients' visual exploration improved in the active viewing condition. However, patients looked less at task-relevant objects and looked more at distractors than controls in the active viewing condition in which they were asked to picture themselves making a sandwich in moving their eyes to task-relevant objects on an image. These results are consistent with the literature on deficits in motor imagery in patients with schizophrenia and it extends the impairment to visual exploration in an action imagery task.

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Section: Discussionmentioning

confidence: 99%

Imagined motor action and eye movements in schizophrenia

Delerue

Boucart

2013

Front. Psychol.

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Relationship between exploratory eye movements and brain morphology in schizophrenia spectrum patients

Tsunoda

Kawasaki

Matsui

et al. 2004

Eur Arch Psychiatry Clin Neurosci

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The exploratory eye movements of schizophrenia patients and their relatives have been shown to differ from those of patients without schizophrenia and healthy controls. However the mechanism of exploratory eye movement disturbances in schizophrenia patients remains elusive. We investigated the relationship between the exploratory eye movements and brain morphology in 39 schizophrenia spectrum patients. Voxel-based morphometric analysis on three-dimensional magnetic resonance imaging was conducted by means of statistical parametric mapping 99. The decrease in the responsive search score, which is the total number of sections on which the eyes fixed in response to questioning in a comparison task, was significantly correlated with the decreased gray matter in the right frontal eye field (rFEF) including the right supplementary eye field (rSEF), right parietal eye field (rPEF), and right inferior frontal region. These results suggest that disturbance in exploratory eye movement in schizophrenia spectrum patients may be related to neural network dysfunction in FEF, SEF and PEF, which are the eye movement related areas, and in the inferior frontal region that may be related to information organization.

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Exploratory eye movement dysfunction as a discriminator for schizophrenia

Suzuki

Takahashi

Matsushima

et al. 2009

Eur Arch Psychiatry Clin Neurosci

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In our previous studies, we identified that exploratory eye movement (EEM) dysfunction appears to be specific to schizophrenia. The availability of a biological marker specific to schizophrenia would be useful for clinical diagnosis of schizophrenia. Consequently, we performed the discriminant analysis between schizophrenics and non-schizophrenics on a large sample using the EEM test data and examined an application of the EEM for clinical diagnosis of schizophrenia. EEM performances were recorded in 251 schizophrenics and 389 non-schizophrenics (111 patients with mood disorders, 28 patients with neurotic disorders and 250 normal controls). The patients were recruited from eight university hospitals and three affiliated hospitals. For this study with a large sample, we developed a new digital computerized version of the EEM test, which automatically handled large amounts of data. We measured four parameters: number of eye fixations (NEF), total eye scanning length (TESL), mean eye scanning length (MESL) and responsive search score (RSS). These parameters of schizophrenics differed significantly from those of the other three groups. The stepwise regression analysis selected the TESL and the RSS as the valid parameters for discriminating between schizophrenics and non-schizophrenics. In the discriminant analysis using the RSS and TESL as prediction parameters, 184 of the 251 clinically diagnosed schizophrenics were discriminated as having schizophrenia (sensitivity 73.3%); and 308 of the 389 clinically diagnosed non-schizophrenic subjects were discriminated as non-schizophrenics (specificity 79.2%). Based on our findings we believe that the EEM measures may be useful for the clinical diagnosis of schizophrenia.

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Exploratory eye movements in schizophrenia

Cited by 18 publications

References 23 publications

Imagined motor action and eye movements in schizophrenia

Imagined motor action and eye movements in schizophrenia

Relationship between exploratory eye movements and brain morphology in schizophrenia spectrum patients

Exploratory eye movement dysfunction as a discriminator for schizophrenia

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