Exploratory Evaluation of Pre-Treatment Inflammation Profiles in Patients with Colorectal Cancer

Abstract

In light of the elevated incidence and consequential prognostic implications associated with colorectal cancer, a comprehensive investigation into the impact exerted by inflammatory status on patient management becomes imperative. A retrospective study spanning 7 years was conducted, involving the retrospective collection of data on colorectal cancer patients undergoing surgical intervention. We evaluated six inflammation ratios derived from complete peripheral blood counts. A thorough analysis of these markers’ prognostic capacity was conducted, revealing that patients who died postoperatively displayed significantly higher preoperative Aggregate Index of Systemic Inflammation—AISI (p = 0.014) and Systemic Inflammation Response Index—SII (p = 0.0197) levels compared to those with successful discharge. Noteworthy variations in neutrophil-to-lymphocyte ratio (p = 0.0103), platelet-to-lymphocyte ratio (p = 0.0041), AISI (p < 0.001), and SII (p = 0.0045) were observed in patients necessitating postoperative Intensive Care Unit (ICU) monitoring. Furthermore, patients with complications, such as an intestinal fistula, exhibited significantly elevated AISI (p = 0.0489). Inflammatory biomarkers stand out as valuable prognostic tools for colorectal cancer patients, offering potential assistance in predicting their prognosis.

An Exploratory Assessment of Pre-Treatment Inflammatory Profiles in Gastric Cancer Patients

“…The inflammatory status of patients assessed through the analysis of these ratios plays a significant role in evaluating the prognosis of patients undergoing surgery for malignant pathologies. Significant changes in the potential predictive value of these preoperative ratios have been highlighted not only in patients undergoing surgery for gastric cancer but also in patients undergoing surgery for colorectal cancer [24][25][26], and even in patients undergoing lung cancer treatment [27,28]. While experimentally verified reference values for the mentioned ratios are not available, the specialized literature presents retrospective studies (with their well-known limitations) demonstrating the potential of these ratios in determining patient prognosis.…”