2020
DOI: 10.3389/fpsyt.2020.00124
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Exploratory Analysis of Behavioral Impulsivity, Pro-inflammatory Cytokines, and Resting-State Frontal EEG Activity Associated With Non-suicidal Self-Injury in Patients With Mood Disorder

Abstract: Introduction: Non-suicidal self-injury (NSSI) is a rapidly increasing mental health problem that requires more clinical attention. In this study, we aimed to explore the biobehavioral markers of NSSI in participants with mood disorders. Methods: A total of 45 participants with mood disorders (bipolar I, II, and major depressive disorder) were included in the study. Behavioral impulsivity was measured using the immediate memory task (IMT)/delayed memory task (DMT) and the go-no-go (GNG) tests. Plasma levels of … Show more

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Cited by 26 publications
(15 citation statements)
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“…Additionally, NSSI was related to greater behavioral impulsivity and increased serum TNF-α levels. Therefore, frontal dysfunction associated with greater inflammation might explain the neurobiological basis of NSSI [ 58 ]. The hypothalamic-pituitary-adrenal (HPA) axis seems to be a potential mechanism that may explain the link between sleep deprivation and NSSI.…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, NSSI was related to greater behavioral impulsivity and increased serum TNF-α levels. Therefore, frontal dysfunction associated with greater inflammation might explain the neurobiological basis of NSSI [ 58 ]. The hypothalamic-pituitary-adrenal (HPA) axis seems to be a potential mechanism that may explain the link between sleep deprivation and NSSI.…”
Section: Discussionmentioning
confidence: 99%
“…Glutamate is the most excitatory neurotransmitter in the brain, but numerous neurotransmitter molecules work constantly to maintain the brain functioning, including cholinergic and monoaminergic (serotonin, dopamine, and noradrenaline) neurotransmitters. Neurodegeneration can result from the alterations in the balance of neurotransmitters (Arai et al, 2004;Harris et al, 2014;Kim et al, 2020;Korte-Bouws et al, 2018;Tyagi et al, 2008;Vakalopoulos, 2014). Inflammation was previously reported to alter the neurotransmitter metabolism, and thus affects frontal neuronal activity (Yamanashi et al, 2021).…”
Section: Discussionmentioning
confidence: 99%
“…Additionally, NSSI was related to greater behavioral impulsivity and increased serum TNF-α level. Therefore, frontal dysfunction associated with greater in ammation might explain the neurobiological basis of NSSI [58]. The hypothalamic-pituitary-adrenal (HPA) axis seems as one potential mechanism that may explain the link between sleep deprivation and NSSI.…”
Section: Discussionmentioning
confidence: 99%