Exploration of vitamin D metabolic activity-related biological effects and corresponding therapeutic targets in prostate cancer
Lei Ding,
Yong Wang,
Zhentao Tang
et al.
Abstract:Background
Previous studies have unequivocally demonstrated that the vitamin D (VD) metabolism pathway significantly influences prognosis and sensitivity to hormone therapy in prostate cancer (PCa). However, the precise underlying mechanism remains unclear.
Methods
We performed molecular profiling of 1045 PCa patients, leveraging genes linked to VD synthesis and VD receptors. We then identified highly variable gene modules with substantial associat… Show more
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