Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors

Xiong, Huilan; Yu, Qiuchun; Ma, Haowen; Yu, Xiuwen; Ouyang, Yifan; Zhang, Zhimin; Zhou, Wei; Zhang, Zhang; Cai, Qian

doi:10.1039/d3md00209h

RSC Med. Chem.

2023

DOI: 10.1039/d3md00209h

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Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors

Huilan Xiong¹,

Qiuchun Yu²,

Haowen Ma³

et al.

Abstract: Right open reading frame kinase 2 (RIOK2) is an atypical kinase and has been proved to be involved in multiple human cancers including non-small cell lung cancer (NSCLC), acute myeloid...

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Benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidines: Past and Present

2023

IgMin Res

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Synthetic approaches to the construction of the heterocyclic benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidine system based on heterocyclizations of substituted benzimidazoles and a new alternative strategy based on 2,4,6-trisubstituted pyrimidinyl-5-propanoic acids are considered. The latter method has been shown to be a successful addition to previously described methods, since it allows one to bypass the significant limitations associated with the use of substituted benzimidazoles and allows the introduction of functional substituents at different positions of the heterocycle that are inaccessible by other methods. The available information on derivatives of this heterocyclic system and their biological properties is summarized.

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Benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidines: Past and Present

2023

IgMin Res

View full text Add to dashboard Cite

show abstract

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Exploration of tricyclic heterocycles as core structures for RIOK2 inhibitors

Abstract: Right open reading frame kinase 2 (RIOK2) is an atypical kinase and has been proved to be involved in multiple human cancers including non-small cell lung cancer (NSCLC), acute myeloid...

Cited by 1 publication

References 20 publications

Benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidines: Past and Present

Benzo[4’,5’]imidazo[2’,1’:6,1]pyrido[2,3-d]pyrimidines: Past and Present

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