Exploration of the synergistic inhibition of 4-methylimidazole and 5-hydroxymethylfurfural in caramel colors by amino acid combinations and potential mechanisms

Zhang, Zening; Deng, Peng; Chen, Yang; He, Zhiyong; Qin, Fang; Chen, Qiuming; Wang, Zhaojun; Chen, Jie; Zeng, Maomao; Pan, Hongyang

doi:10.1016/j.fbio.2023.103471

Cited by 1 publication

(2 citation statements)

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“…10 Meanwhile, acrylamide and methylimidazoles have been recognized as potential carcinogens in humans. 11,12 Therefore, it is crucial to mitigate MGO in food and in vivo in order to reduce the deleterious effects of MGO and its dangerous derivatives in vivo. Utilizing natural compounds (such as amino acids and polyphenols) as scavengers for MGO is regarded as the most applicable strategy.…”

Section: Introductionmentioning

confidence: 99%

“…However, MGO present deleterious effects on health as the primary precursor to the production of advanced glycation end-products (AGEs), acrylamide, 2-methylimidazole, and 4(5)-methylimidazole. , Dietary intake of AGEs is strongly associated with the development of many chronic diseases, such as aging, osteoporosis, Alzheimer’s disease, diabetes mellitus, and diabetic complications . Meanwhile, acrylamide and methylimidazoles have been recognized as potential carcinogens in humans. , …”

Section: Introductionmentioning

confidence: 99%

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Formation of Hesperetin-Methylglyoxal Adducts in Food and In Vivo, and Their Metabolism In Vivo and Potential Health Impacts

Zhang,

Ge,

Huang

et al. 2024

J. Agric. Food Chem.

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Polyphenols with a typical meta-phenol structure have been intensively investigated for scavenging of methylglyoxal (MGO) to reduce harmful substances in food. However, less attention has been paid to the formation level of polyphenol-MGO adducts in foods and in vivo and their absorption, metabolism, and health impacts. In this study, hesperitin (HPT) was found to scavenge MGO by forming two adducts, namely, 8-(1-hydroxyacetone)-hesperetin (HPT-mono-MGO) and 6-(1-hydroxyacetone)-8-(1-hydroxyacetone)-hesperetin (HPT-di-MGO). These two adducts were detected (1.6−15.9 mg/kg in total) in cookies incorporated with 0.01%−0.5% HPT. HPT-di-MGO was the main adduct detected in rat plasma after HPT consumption. The adducts were absorbed 8−30 times faster than HPT, and they underwent glucuronidation and sulfation in vivo. HPT-mono-MGO would continue to react with endogenous MGO in vivo to produce HPT-di-MGO, which effectively reduced the cytotoxicity of HPT and HPT-mono-MGO. This study provided data on the safety of employing HPT as a dietary supplement to scavenge MGO in foods.

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Section: Introductionmentioning

confidence: 99%