Exploration of the proton conduction behavior in natural neutral polysaccharides for biodegradable organic synaptic transistors

Yang, Yahan; Zhao, Xiaoli; Wang, Shuya; Zhang, Cong; Sun, Hongying; Xu, Fan; Tong, Yanhong; Tang, Qingxin; Liu, Yichun

doi:10.1039/d0tc03842c

Cited by 21 publications

(43 citation statements)

References 40 publications

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“…OSTs composed of fully non-toxic materials including natural biomaterials have been demonstrated as a solution to these problems. [57,58] The OSTs were fabricated by using dinaphtho[2,3-b:2″,3″-f ] thieno[3,2-b]-thiophen (DNTT) as a semiconductor, Au as source/drain/gate electrodes, and dextran as a gate insulator. Dextran is a natural polysaccharide; this was its first reported use as a biocompatible gate insulator in an OST.…”

Section: Biocompatibilitymentioning

confidence: 99%

Organic Synaptic Transistors for Bio‐Hybrid Neuromorphic Electronics

Kim

Sung

Park

et al. 2021

Adv Elect Materials

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big data computing. By emulating biological nervous systems, this "von Neumann bottleneck" can be solved by using artificial synapses that combine memory and processing functions in one cell, as in biological nervous systems. [1,2] Emulation of biological synapses and nerves also provides the sensing and responding functions with human-like abilities such as event-driven processing and high-accuracy perception, which are limited in conventional human-interactive systems such as e-skins, human-machine interfaces, and neuro-prostheses. [3][4][5][6] In biological nervous systems, sensory signals are evoked by external stimuli (e.g., pressure, light, temperature) and transmitted through sensory nerves in the peripheral nervous system (PNS) to the central nervous system (CNS), that performs perceptual processing of information. Afterward, the processed signal is transmitted along nerves to generate appropriate responses to the stimulus. Neuromorphic systems that emulate biological PNS and CNS may enable energy-efficient operation to process sophisticated real-world problems by detecting and responding to environmental information. The artificial sensory nerves consist of sensors, artificial neurons, and artificial synapses to emulate this perceptual processing. The sensory signals are converted to voltage spikes (i.e., action potentials) by artificial neurons, then processed by artificial synapses. These artificial sensory nerves emulate the event-driven operation of biological nerves and thus consume energy only while responding to inputs. Therefore, artificial nerves consume much less energy than conventional artificial sensory systems, which require periodic scanning of sensing/processing units, and that use standby energy when input is absent. Furthermore, the artificial nerves can be promising for prosthetic applications because they can generate biocompatible spike signals without bulky and rigid external encoding units. [7] After perceptual processing, biological responses can be achieved by stimulating target organs and tissues. Intregration of these neuromorphic systems with biological systems to form so-called "bio-hybrid neuromorphic systems", will realize biomimetic signal transmission and information processing at bio-electronic interfaces. Thus, these systems successfully emulate efficient biological perception processing, that has sensing and responding abilities, and therefore, show promise for use in next-generation healthcare monitoring and neuroprosthetic devices that need to detect bio-signals in a Neuromorphic electronics that emulate biological synapses and nerves can provide a solution to overcome the limitation in energy efficiency of von Neumann computing systems. With increasing demands on bio-medical applications such as healthcare monitoring and neuroprosthetic devices, biohybrid neuromorphic electronics are evaluated as ways to process biological information and replace biological systems. Successful realization of biohybrid neuromorphic systems requires replication of various synaptic pro...

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Section: Biocompatibilitymentioning

confidence: 99%

Organic Synaptic Transistors for Bio‐Hybrid Neuromorphic Electronics

Kim

Sung

Park

et al. 2021

Adv Elect Materials

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“…Dextran is a neutral polysaccharide without dissociating protons from its molecular chain. Its molecular structure, with excellent hydrophilicity, facilitates the formation of a hydrogen-bonding network and provides a large number of proton transfer sites [ 22 ]. As a matter of fact, water molecules inevitably remain in the dextran film as a result of the solution preparation and its hydroxyl groups.…”

Section: Resultsmentioning

confidence: 99%

“…Hence, protons may come from the self-dissociation of water, and the highly proton-conductive property of the dextran–chitosan matrix stems from the hydrogen-bond network between dextran and chitosan. After a bias sweeping process, the protons were successively accumulated at the nanocomposite/electrode interface and the chitosan/dextran interface [ 22 , 36 ]. From the slopes of the I–V curves in state I and II, the current changes were based on low-exponent space-charge-limited current (SCLC) as the voltage increased.…”

Section: Resultsmentioning

confidence: 99%

“…Therefore, the physical mechanism for the biomemristic behaviors of ITO/dextran–chitosan/Ni is predominantly attributed to the SCLC theory and results from the charge trapping/detrapping process with different filling ratios of protons in the trapping sites. The increase in dextran contributes to a higher level of water absorption in the dextran–chitosan film, which can produce more proton-conducting hydrogen bond chains that serve as proton wires for Grotthuss-type transfer [ 22 ].…”

Section: Resultsmentioning

confidence: 99%

“…Dextran is a nontoxic and biodegradable natural polysaccharide that is employed in the medical domain as a blood substitute, a polymeric carrier in the delivery of drugs, a plasma expander, and for bone healing [ 21 ]. Its molecular structure with excellent hydrophilicity contributes to the formation of a hydrogen-bond network and supplies a large number of proton transfer sites [ 22 ]. The neutral polysaccharide dextran, with proton conductive properties, provides a meaningful direction for biomemristors based on neutral polymers and advances the development of neutral natural biomaterials in biodegradable neuromorphic systems.…”

Section: Introductionmentioning

confidence: 99%

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Multi-Bit Biomemristic Behavior for Neutral Polysaccharide Dextran Blended with Chitosan

2022

Nanomaterials

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Natural biomaterials applicable for biomemristors have drawn prominent attention and are of benefit to sustainability, biodegradability, biocompatibility, and metabolism. In this work, multi-bit biomemristors based on the neutral polysaccharide dextran were built using the spin-casting method, which was also employed to explore the effect of dextran on the ternary biomemristic behaviors of dextran–chitosan nanocomposites. The doping of 50 wt% dextran onto the bio-nanocomposite optimized the ratio of biomemristance in high-, intermediate-, and low-resistance states (105:104:1). The interaction between dextran and chitosan (hydrogen-bond network) was verified by Fourier transform infrared (FTIR) and Raman spectroscopy analysis; through this interaction, protons derived from the self-dissociation of water may migrate under the electric field, and so proton conduction may be the reason for the ternary biomemristic behaviors. Observations from X-ray diffraction (XRD), thermogravimetric analysis (TGA), and differential scanning calorimetry (DSC) analysis displayed that the 50 wt% dextran/50 wt% chitosan nanocomposite had the greatest amorphous ratio as well as the highest decomposition and peak transition temperatures in comparison with the other three dextran–chitosan nanocomposites. This work lays the foundation for neutral biomaterials applied to green ultra-high-density data-storage systems.

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Biodegradable Materials for Transient Organic Transistors

Stephen

Nawaz

Lee

et al. 2022

Adv Funct Materials

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Electronic devices that can physically disappear in a controlled manner without harmful by-products unveil a wide range of opportunities in medical devices, environmental monitoring, and next-generation consumer electronics. Their property of transience is indispensable for mitigating the global problem of electronic waste accumulation. Additionally, transient technologies that are biocompatible and can be biologically resorbed are of great potential for applications in temporary medical implants, since it eliminates the need for expensive device recovery surgery. Transistors are the key building blocks of modern electronics, and their fabrication using organic materials is beneficial due to their low cost, unprecedented flexibility and facile processing. This contribution reviews the technological application of biodegradable materials in four major classes of organic transistors, namely organic field-effect transistors (OFETs), organic synaptic transistors, electrolyte-gated OFETs, and organic electrochemical transistors. The fundamental biodegradation mechanism is discussed in detail, followed by a perspective of various biodegradable materials utilized as active semiconductors, dielectrics, electrolytes and substrates in the various types of organic transistor devices. This contribution comprehensively discusses the role and application of biodegradable materials in all of the key modern-day organic transistors, highlighting their unique properties that allow the fabrication of biodegradable, eco-friendly, and sustainable devices.

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Exploration of the proton conduction behavior in natural neutral polysaccharides for biodegradable organic synaptic transistors

Abstract: Natural biomaterials have recently attracted growing interests for the construction of artificial synaptic transistors, since as-fabricated electronic devices are typically sustainable, biodegradable, biocompatible, and metabolizable. Most importantly, proton conduction has...

Cited by 21 publications

References 40 publications

Organic Synaptic Transistors for Bio‐Hybrid Neuromorphic Electronics

Organic Synaptic Transistors for Bio‐Hybrid Neuromorphic Electronics

Multi-Bit Biomemristic Behavior for Neutral Polysaccharide Dextran Blended with Chitosan

Biodegradable Materials for Transient Organic Transistors

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