Exploration of the mode of death and potential death mechanisms of nucleus pulposus cells
Daqian Zhou,
Yongliang Mei,
Chao Song
et al.
Abstract:Intervertebral disc degeneration (IVDD) is a common chronic orthopaedic disease in orthopaedics that imposes a heavy economic burden on people and society. Although it is well established that IVDD is associated with genetic susceptibility, ageing and obesity, its pathogenesis remains incompletely understood. Previously, IVDD was thought to occur because of excessive mechanical loading leading to destruction of nucleus pulposus cells (NPCs), but studies have shown that IVDD is a much more complex process assoc… Show more
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