Exploration of the Mechanism of the Control of Coccidiosis in Chickens Based on Network Pharmacology and Molecular Docking With the Addition of Modified Gegen Qinlian Decoction

Peng, Xiaomin; Wang, Kaijun; Wang, Yuhan; Lu, Yujie; Lv, Feng; Cui, Yao; Wang, Ying; Si, Hongbin

doi:10.3389/fvets.2022.849518

Cited by 4 publications

(5 citation statements)

References 53 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Importantly, GQD could treat cecum lesions and bloody diarrhea in chickens infected with Eimeria tenella to improve growth performance via the targets SRC, STAT, and PPARG [187]. In a comparative pharmacokinetic study, the absorption of Puerarin, Wogonin, and Daidzein increased in the E. coli infective diarrhea minipig model compared to the control group.…”

Section: Gegen-qinlian Decoction (Gqd)mentioning

confidence: 99%

“…These properties are based on seven typical crude herbs and their bioactive ingredients. By combining various types of herbs, the stringent "sovereign, minister, as- [174][175][176]178,179,[182][183][184][185]187,190,191].…”

Section: Banxia Xiexin Decoction (Bxd)mentioning

confidence: 99%

“…Figure 3. Mechanisms associated with the role of GQD in intestinal inflammation[174][175][176]178,179,[182][183][184][185]187,190,191].…”

mentioning

confidence: 99%

See 2 more Smart Citations

Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals

Yang,

Xiao,

Cheng

et al. 2023

Molecules

View full text Add to dashboard Cite

Intestinal inflammation is a chronic gastrointestinal disorder with uncertain pathophysiology and causation that has significantly impacted both the physical and mental health of both people and animals. An increasing body of research has demonstrated the critical role of cellular signaling pathways in initiating and managing intestinal inflammation. This review focuses on the interactions of three cellular signaling pathways (TLR4/NF-κB, PI3K-AKT, MAPKs) with immunity and gut microbiota to explain the possible pathogenesis of intestinal inflammation. Traditional medicinal drugs frequently have drawbacks and negative side effects. This paper also summarizes the pharmacological mechanism and application of Chinese herbal compounds (Berberine, Sanguinarine, Astragalus polysaccharide, Curcumin, and Cannabinoids) and formulae (Wumei Wan, Gegen-Qinlian decoction, Banxia xiexin decoction) against intestinal inflammation. We show that the herbal compounds and formulae may influence the interactions among cell signaling pathways, immune function, and gut microbiota in humans and animals, exerting their immunomodulatory capacity and anti-inflammatory and antimicrobial effects. This demonstrates their strong potential to improve gut inflammation. We aim to promote herbal medicine and apply it to multispecies animals to achieve better health.

show abstract

Section: Gegen-qinlian Decoction (Gqd)mentioning

confidence: 99%

Section: Banxia Xiexin Decoction (Bxd)mentioning

confidence: 99%

See 1 more Smart Citation

Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals

Yang,

Xiao,

Cheng

et al. 2023

Molecules

View full text Add to dashboard Cite

show abstract

“…Network pharmacology uses extensive databases to systematically determine the effects and mechanisms of traditional medicine prescriptions in treating complex diseases [ 13 ]. This method enables broad predictions of potential mechanisms of action, corresponding component targets and disease targets for treating disease [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction

Lee,

Seo,

Lee

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

Scutellaria baicalensis Georgi and Raphanus Sativus Linne herbal mixture (SRE) is a Chinese herbal medicine. In this study, we aimed to evaluate the therapeutic efficacy of SRE as an active ingredient for 2,4-dinitrochlorobenzene (DNCB)-induced atopic dermatitis (AD) and to predict the underlying therapeutic mechanisms and involved pathways using network pharmacological analysis. Treatment with SRE accelerated the development of AD-like lesions, improving thickness and edema of the epidermis. Moreover, administering the SRE to AD-like mice suppressed immunoglobulin E and interleukin-4 cytokine and reduced T lymphocyte differentiation. In silico, network analysis was used to predict the exact genes, proteins, and pathways responsible for the therapeutic effect of the SRE against DNCB-induced AD. These results indicated that the SRE exerted protective effects on the DNCB-induced AD-like model by attenuating histopathological changes and suppressing the levels of inflammatory mediators. Therefore, the SRE can potentially be a new remedy for improving AD and other inflammatory diseases and predicting the intracellular signaling pathways and target genes involved. This therapeutic effect of the SRE on AD can be used to treat DNCB-induced AD and its associated symptoms.

show abstract

“…Traditional Chinese medicine employs multiple compounds with multiple targets to improve efficacy compared to the use of single-target drugs [ 27 , 28 ]. Network pharmacology can be used to construct a compound-protein/gene-disease network to predict complex drug-target interactions [ 29 , 30 ], and has been widely used in research on viruses [ 31 ], bacteria [ 32 ] and parasites [ 33 ].…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic, 16S ribosomal ribonucleic acid and network pharmacology analyses shed light on the anticoccidial mechanism of green tea polyphenols against Eimeria tenella infection in Wuliangshan black-boned chickens

Song,

Deng,

Yang

et al. 2023

Parasites Vectors

View full text Add to dashboard Cite

Background Eimeria tenella is an obligate intracellular parasitic protozoan that invades the chicken cecum and causes coccidiosis, which induces acute lesions and weight loss. Elucidating the anticoccidial mechanism of action of green tea polyphenols could aid the development of anticoccidial drugs and resolve the problem of drug resistance in E. tenella. Methods We constructed a model of E. tenella infection in Wuliangshan black-boned chickens, an indigenous breed of Yunnan Province, China, to study the efficacy of green tea polyphenols against the infection. Alterations in gene expression and in the microbial flora in the cecum were analyzed by ribonucleic acid (RNA) sequencing and 16S ribosomal RNA (rRNA) sequencing. Quantitative real-time polymerase chain reaction was used to verify the host gene expression data obtained by RNA sequencing. Network pharmacology and molecular docking were used to clarify the interactions between the component green tea polyphenols and the targeted proteins; potential anticoccidial herbs were also analyzed. Results Treatment with the green tea polyphenols led to a reduction in the lesion score and weight loss of the chickens induced by E. tenella infection. The expression of matrix metalloproteinase 7 (MMP7), MMP1, nitric oxide synthase 2 and ephrin type-A receptor 2 was significantly altered in the E. tenella infection plus green tea polyphenol-treated group and in the E. tenella infection group compared with the control group; these genes were also predicted targets of tea polyphenols. Furthermore, the tea polyphenol (-)-epigallocatechin gallate acted on most of the targets, and the molecular docking analysis showed that it has good affinity with interferon induced with helicase C domain 1 protein. 16S ribosomal RNA sequencing showed that the green tea polyphenols had a regulatory effect on changes in the fecal microbiota induced by E. tenella infection. In total, 171 herbs were predicted to act on two or three targets in MMP7, MMP1, nitric oxide synthase 2 and ephrin type-A receptor 2. Conclusions Green tea polyphenols can directly or indirectly regulate host gene expression and alter the growth of microbiota. The results presented here shed light on the mechanism of action of green tea polyphenols against E. tenella infection in chickens, and have implications for the development of novel anticoccidial products. Graphical Abstract

show abstract

Exploration of the Mechanism of the Control of Coccidiosis in Chickens Based on Network Pharmacology and Molecular Docking With the Addition of Modified Gegen Qinlian Decoction

Cited by 4 publications

References 53 publications

Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals

Protective Application of Chinese Herbal Compounds and Formulae in Intestinal Inflammation in Humans and Animals

Anti-Atopic Effect of Scutellaria baicalensis and Raphanus sativus on Atopic Dermatitis-like Lesions in Mice by Experimental Verification and Compound-Target Prediction

Transcriptomic, 16S ribosomal ribonucleic acid and network pharmacology analyses shed light on the anticoccidial mechanism of green tea polyphenols against Eimeria tenella infection in Wuliangshan black-boned chickens

Contact Info

Product

Resources

About