Exploration of the link between gut microbiota and purinergic signalling

Li, MingJian; Liu, Bowen; Li, Rong; Yang, Ping; Leng, Ping; Huang, Yong

doi:10.1007/s11302-022-09891-1

Cited by 15 publications

(10 citation statements)

References 97 publications

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“…In addition, B. uniformis was positively correlated with pathways involved in the de novo synthesis of various purines, nucleotides and deoxynucleotides. Purinergic signalling serves as one of the linkages between gut microbiota and immune function [ 20 ]. Extracellular adenosine triphosphate (ATP) produced from these pathways can promote the maturation of DCs and stimulation of B and T cells by activating the P2X receptor [ 20 , 21 , 22 ].…”

Section: Discussionmentioning

confidence: 99%

“…Purinergic signalling serves as one of the linkages between gut microbiota and immune function [ 20 ]. Extracellular adenosine triphosphate (ATP) produced from these pathways can promote the maturation of DCs and stimulation of B and T cells by activating the P2X receptor [ 20 , 21 , 22 ]. B. uniformis was also significantly correlated with pathways that produced beneficial products.…”

Section: Discussionmentioning

confidence: 99%

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The Predictive Value of Gut Microbiota Composition for Sustained Immunogenicity following Two Doses of CoronaVac

Ng,

Liao,

Zhang

et al. 2024

IJMS

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CoronaVac immunogenicity decreases with time, and we aimed to investigate whether gut microbiota associate with longer-term immunogenicity of CoronaVac. This was a prospective cohort study recruiting two-dose CoronaVac recipients from three centres in Hong Kong. We collected blood samples at baseline and day 180 after the first dose and used chemiluminescence immunoassay to test for neutralizing antibodies (NAbs) against the receptor-binding domain (RBD) of wild-type SARS-CoV-2 virus. We performed shotgun metagenomic sequencing performed on baseline stool samples. The primary outcome was the NAb seroconversion rate (seropositivity defined as NAb ≥ 15AU/mL) at day 180. Linear discriminant analysis [LDA] effect size analysis was used to identify putative bacterial species and metabolic pathways. A univariate logistic regression model was used to derive the odds ratio (OR) of seropositivity with bacterial species. Of 119 CoronaVac recipients (median age: 53.4 years [IQR: 47.8–61.3]; male: 39 [32.8%]), only 8 (6.7%) remained seropositive at 6 months after vaccination. Bacteroides uniformis (log10LDA score = 4.39) and Bacteroides eggerthii (log10LDA score = 3.89) were significantly enriched in seropositive than seronegative participants. Seropositivity was associated with B. eggerthii (OR: 5.73; 95% CI: 1.32–29.55; p = 0.022) and B. uniformis with borderline significance (OR: 3.27; 95% CI: 0.73–14.72; p = 0.110). Additionally, B. uniformis was positively correlated with most enriched metabolic pathways in seropositive vaccinees, including the superpathway of adenosine nucleotide de novo biosynthesis I (log10LDA score = 2.88) and II (log10LDA score = 2.91), as well as pathways related to vitamin B biosynthesis, all of which are known to promote immune functions. In conclusion, certain gut bacterial species (B. eggerthii and B. uniformis) and metabolic pathways were associated with longer-term CoronaVac immunogenicity.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Predictive Value of Gut Microbiota Composition for Sustained Immunogenicity following Two Doses of CoronaVac

Ng,

Liao,

Zhang

et al. 2024

IJMS

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“…The purD gene is required for de novo purine nucleotide biosynthesis, which is conserved across the divisions of life (Yamamoto et al, 2022). Aside from being critical components of DNA and RNA, purine metabolites are involved in diverse signaling processes, in which the involvement of the gut microbiome is increasingly recognized (Li et al, 2022). Interestingly, humans carry a mutation in the ADSL gene that reduces the level of de novo synthesis of purines compared to other primates, suggesting that large-scale differences in purinergic signaling traits can evolve at the host level (Stepanova et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Comparative genomics of novel Bacteroides acidifaciens isolates reveals candidates for adaptation to host subspecies in house mice

Fokt

Rühlemann

Godfroid

et al. 2023

Preprint

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The breadth of phenotypes influenced by the gut microbiome in multicellular hosts has attracted the keen and renewed interest of evolutionary biologists. Comparative studies suggest that coevolutionary processes may occur as hosts and their associated microbes (i.e., holobionts) diverge. The majority of studies to date however lack information beyond that of 16S rRNA gene profiling, and thus fail to capture potential underlying genomic changes among microbes. In this study, we conducted a comparative genomic analysis of 19 newly sampled Bacteroides acidifaciens isolates derived from the eastern and western house mouse subspecies, Mus musculus musculus and M. m. domesticus. Through a panel of genome-wide association (GWAS) analyses applied to pangenomic content, structural gene rearrangements, and SNPs, we reveal several candidates for adaptation to the host subspecies environment. The proportion of significant loci in each respective category is small, indicating low levels of differentiation according host subspecies. However, consistent signal is observed for genes involved in processes such as carbohydrate acquisition/utilization (SusD/RagB, amyA and amyS) and de novo purine nucleotide biosynthesis (purD), which serve as promising candidates for future experimental investigation in the house mouse as a model of holobiont evolution.

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“…It goes without saying that alterations in the composition of the gut microbiome and in the levels of microbiome-derived metabolites are associated with IBD [ 114 , 115 , 116 , 117 , 118 ]. In the landscape of adenosine signaling, the intestinal microbiota is also known to secrete the adenosine precursor, ATP [ 119 , 120 , 121 ]. Meanwhile, Lactobacillus reuteri treatment has been shown to induce expansion of beneficial gut microbiota and augment the plasma levels of adenosine in mice [ 122 ] ( Table 1 ).…”

Section: Contributions Of the Gut Microbiome To Adenosine-mediated Ba...mentioning

confidence: 99%

Adenosine in Intestinal Epithelial Barrier Function

Stepanova,

Aherne

2024

Cells

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At the intestinal front, several lines of defense are in place to resist infection and injury, the mucus layer, gut microbiome and strong epithelial junctions, to name a few. Their collaboration creates a resilient barrier. In intestinal disorders, such as inflammatory bowel disease (IBD), barrier function is compromised, which results in rampant inflammation and tissue injury. In response to the destruction, the intestinal epithelium releases adenosine, a small but powerful nucleoside that functions as an alarm signal. Amidst the chaos of inflammation, adenosine aims to restore order. Within the scope of its effects is the ability to regulate intestinal epithelial barrier integrity. This review aims to define the contributions of adenosine to mucus production, microbiome-dependent barrier protection, tight junction dynamics, chloride secretion and acid–base balance to reinforce its importance in the intestinal epithelial barrier.

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Exploration of the link between gut microbiota and purinergic signalling

Cited by 15 publications

References 97 publications

The Predictive Value of Gut Microbiota Composition for Sustained Immunogenicity following Two Doses of CoronaVac

The Predictive Value of Gut Microbiota Composition for Sustained Immunogenicity following Two Doses of CoronaVac

Comparative genomics of novel Bacteroides acidifaciens isolates reveals candidates for adaptation to host subspecies in house mice

Adenosine in Intestinal Epithelial Barrier Function

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