Exploration of the In Vitro Violacein Synthetic Pathway with Substrate Analogues
Shelby L. Hooe,
Meghna Thakur,
Guillermo Lasarte-Aragonés
et al.
Abstract:Evolution has gifted enzymes with the ability to synthesize an abundance of small molecules with incredible control over efficiency and selectivity. Central to an enzyme's role is the ability to selectively catalyze reactions in the milieu of chemicals within a cell. However, for chemists it is often desirable to extend the substrate scope of reactions to produce analogue(s) of a desired product and therefore some degree of enzyme promiscuity is often desired. Herein, we examine this dichotomy in the context o… Show more
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