Exploration of the global antioxidant capacity of the stratum corneum by cyclic voltammetry

Electrochemical behaviour of N-acetyl-l-cysteine on gold electrode—A tentative reaction mechanism

“…Electrochemistry represents a welldefined methodology to study redox properties of antioxidant species, in model solution as well as in complex media. Previous works performed in the laboratory have shown possibilities to evaluate the antioxidant capacity of various media such as wine [15], skin [16], or dermocosmetic creams [17], by simple electrochemical measurements. Furthermore it has also been possible to determine and sometimes quantify the major redox markers involved without any pre-treatment of the sample.…”

Electrochemical Methods for Total Antioxidant Capacity and its Main Contributors Determination: A review

“…Cyclic voltammetry also proved reliable with respect to the determination of total antioxidant capacity of plasma, other body fluids and animal tissue homogenates, imparted mainly by the contribution of low molecular weight antioxidants [49,[58][59][60][61][62].…”

“…This technique enabled a rapid, accurate and non-invasive determination of the total antioxidant capacity of the stratum corneum with results obtained in less than 1 minute. The analytical signal reflected regular alterations of the redox characteristics of the voltammetric microsensor [62].…”

Electrochemical microsensors for cutaneous surface analysis: Application to the determination of pH and the antioxidant properties of stratum corneum

“…These variations certainly resulted from a modification of the electrode surface state induced by the electrochemical oxidation of the antioxidant species [16]. Consequently, the evaluation of repeatability, by means of the standard deviation of the signal obtained with the same electrode placed on the same skin surface, was therefore impossible and our microelectrodes were single use.…”

“…Preliminary works have shown the possibility to perform electrochemical measurements on the human epidermis surface by means of microelectrodes [15,16]. They allowed to realize no invasive, direct (without adding water or gel), rapid and reliable measurements with high spatiotemporal resolution.…”