Exploration of restless legs syndrome under the new concept: A review

Abstract

Restless leg syndrome (Restless legs syndrome, RLS) is a common neurological disorder. The pathogenesis of RLS remains unknown, and recent pathophysiological developments have shown the contribution of various genetic markers, neurotransmitter dysfunction, and iron deficiency to the disease, as well as other unidentified contributing mechanisms, particularly chronic renal dysfunction. RLS enhancement syndrome is frequently observed in patients with RLS who have received long-term dopamine agonist therapy, manifesting as a worsening of RLS symptoms, usually associated with an increase in the dose of dopamine agonist. Some patients with RLS can adequately control their symptoms with non-pharmacological measures such as massage and warm baths. First-line treatment options include iron supplementation for those with evidence of reduced iron stores, or gabapentin or pregabalin, as well as dopamine agonists, such as pramipexole. Second-line therapies include opioids such as tramadol. RLS seriously affects the quality of life of patients, and because its pathogenesis is unclear, more biological evidence and treatment methods need to be explored.Abbreviations: BID = brain iron deficiency, CNS = central nervous system, GABA = gamma-aminobutyric acid, IRLSSG = International restless leg syndrome research group, PLMD = periodic limb movement disorder, PLMS = periodic leg movement in sleep, RLS = restless legs syndrome, WED = Willis-Ekbom disease.

Síndrome das Pernas Inquietas: Bases Fisiopatológicas e Terapêuticas

“…Como alternativa, o fumarato ferroso pode ser considerado, sendo administrado em uma dose de 65 mg de ferro elementar aproximadamente 1 hora antes das refeições para otimizar a absorção (Liu et al, 2022).…”

“…é a tentativa de rotação sequencial da monoterapia, explorando diferentes classes de medicamentos(Liu et al, 2022).METODOLOGIAO atual estudo consistiu em uma revisão bibliográfica, cuja busca foi conduzida nas bases de dados PubMed, Scopus e SciELO. Foram incluídos na revisão artigos originais e revisões sistemáticas que abordassem os aspectos fisiopatológicos e o manejo da síndrome das pernas inquietas.…”

Restless Legs Syndrome Pada Pasien Gagal Ginjal Kronis Yang Menjalani Terapi Hemodialisa Di Rsud Raden Mattaher Jambi

“…Salah satu komplikasi yang muncul pada pasien GGK yang menjalani terapi hemodialisa adalah gangguan neurologi yang dikenal sebagai Restless Legs Syndrome (RLS). (Liu, Guan, and Pan 2022). Sindrom ini, juga disebut sebagai penyakit Willis-Ekbom (WED), adalah gangguan sensorimotor yang ditandai oleh dorongan yang tidak tertahankan untuk menggerakkan kaki.…”

The Role of Micronutrients in Neurological Disorders

“…Restless legs syndrome (RLS) is a movement disorder manifesting as an uncontrollable urge to move as a result of painful sensations in the legs with a release of movement. The pathophysiology is not clear, but genetic components, neurotransmitter dysfunction and aberrant brain iron homeostasis are all contributors [90,91]. 6.12.1.…”