“…The primary purpose of the developed swigh-score clonotyping tool is to facilitate the categorization and interpretation of FASTQ, the prevalent data format for presenting raw output from most DNA sequencing workflows. It offers commands that enable users to track the burden and development of a single clonotype, which can detect residual clonal B cells in various tissues, e.g., stem-cell products for autologous stem cell transplant [ 26 ] or blood plasma by sequencing cell-free tumor DNA [ 12 , [27] , [28] , [29] ]. Still, the utility and predictive value of MRD assessment varies among different diagnoses and cancer types, e.g., due to disease kinetics and available biomarkers, which can impact its clinical applicability [ 14 ].…”