Exploration of Potent Cytotoxic Molecules from Fungi in Recent Past to Discover Plausible Anticancer Scaffolds

Shevkar, Chaitrali; Pradhan, Pranali; Armarkar, Ashwini; Pandey, Komal; Kalia, Kiran; Paranagama, P.A.; Kate, Abhijeet S.

doi:10.1002/cbdv.202100976

Cited by 6 publications

(2 citation statements)

References 67 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Among nontoxigenic fungi, endophytic fungi, i.e., symbiotic fungi that colonize various tissues of their host, most often plants, deserve special attention. Endophytes are an excellent source of bioactive compounds with anticancer activity, including those against lung cancer [52][53][54][55][56][57][58]. In addition to endophytic fungi, bioactive metabolites with anticancer properties against lung cancer are synthesized by marine-derived fungi [59][60][61][62] (Table 1).…”

Section: Secondary Metabolites Synthesized By Endophytes and Marine-d...mentioning

confidence: 99%

Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells

et al. 2023

View full text Add to dashboard Cite

Despite the increasing availability of modern treatments, including personalized therapies, there is a strong need to search for new drugs that will be effective in the fight against cancer. The chemotherapeutics currently available to oncologists do not always yield satisfactory outcomes when used in systemic treatments, and patients experience burdensome side effects during their application. In the era of personalized therapies, doctors caring for non-small cell lung cancer (NSCLC) patients have been given a powerful weapon, namely molecularly targeted therapies and immunotherapies. They can be used when genetic variants of the disease qualifying for therapy are diagnosed. These therapies have contributed to the extension of the overall survival time in patients. Nevertheless, effective treatment may be hindered in the case of clonal selection of tumor cells with acquired resistance mutations. The state-of-the-art therapy currently used in NSCLC patients is immunotherapy targeting the immune checkpoints. Although it is effective, some patients have been observed to develop resistance to immunotherapy, but its cause is still unknown. Personalized therapies extend the lifespan and time to cancer progression in patients, but only those with a confirmed marker qualifying for the treatment (gene mutations/rearrangements or PD-L1 expression on tumor cells) can benefit from these therapies. They also cause less burdensome side effects than chemotherapy. The article is focused on compounds that can be used in oncology and produce as few side effects as possible. The search for compounds of natural origin, e.g., plants, bacteria, or fungi, exhibiting anticancer properties seems to be a good solution. This article is a literature review of research on compounds of natural origin that can potentially be used as part of NSCLC therapies.

show abstract

Section: Secondary Metabolites Synthesized By Endophytes and Marine-d...mentioning

confidence: 99%

Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells

et al. 2023

View full text Add to dashboard Cite

show abstract

“…Obviously, the probability of the discovery of novel structural active substances from microbes in conventional environments has gradually declined. It is crucial to actively search for new microbial resources to advance the research and development of natural product drugs (Nursyam, 2017;Shevkar et al, 2022).…”

Section: Introductionmentioning

confidence: 99%

Chemical synthesis and mechanism of a natural product from endolichenic fungus with a broad-spectrum anti microorganism activity

et al. 2023

View full text Add to dashboard Cite

BackgroundThe antibiotic resistance in various bacteria is consistently increasing and is posing a serious threat to human health, prompting the need for the discovery of novel structurally featured natural products with promising biological activities in drug research and development. Endolichenic microbes have been proven to be a fertile source to produce various chemical components, and therefore these microbes have been on a prime focus for exploring natural products. In this study, to explore potential biological resources and antibacterial natural products, the secondary metabolites of an endolichenic fungus have been investigated.MethodsThe antimicrobial products were isolated from the endolichenic fungus using various chromatographic methods, and the antibacterial and antifungal activities of the compounds were evaluated by the broth microdilution method under in vitro conditions. The antimicrobial mechanism has been discussed with measuring the dissolution of nucleic acid and protein, as well as the activity of alkaline phosphatase (AKP) in preliminary manner. Chemical synthesis of the active product compound 5 was also performed, starting from commercially available 2,6-dihydroxybenzaldehyde through a sequence of transformations that included methylation, the addition of propylmagnesium bromide on formyl group, the oxidation of secondary alcohol, and the deprotection of methyl ether motif.ResultsAmong the 19 secondary metabolites of the endolichenic fungus, Daldinia childiae (compound 5) showed attractive antimicrobial activities on 10 of the 15 tested pathogenic strains, including Gram-positive bacteria, Gram-negative bacteria, and fungus. The Minimum Inhibitory Concentration (MIC) of compound 5 for Candida albicans 10213, Micrococcus luteus 261, Proteus vulgaris Z12, Shigella sonnet, and Staphylococcus aureus 6538 was identified as 16 μg/ml, whereas the Minimum Bactericidal Concentration (MBC) of other strains was identified as 64 μg/ml. Compound 5 could dramatically inhibit the growth of S. aureus 6538, P. vulgaris Z12, and C. albicans 10213 at the MBC, likely affecting the permeability of the cell wall and cell membrane. These results enriched the library of active strains and metabolites resources of endolichenic microorganisms. The chemical synthesis of the active compound was also performed in four steps, providing an alternative pathway to explore antimicrobial agents.

show abstract

Phoma spp. an untapped treasure of cytotoxic compounds: current status and perspectives

Rai

Zimowska

Gade

et al. 2023

Appl Microbiol Biotechnol

View full text Add to dashboard Cite

Exploration of Potent Cytotoxic Molecules from Fungi in Recent Past to Discover Plausible Anticancer Scaffolds

Cited by 6 publications

References 67 publications

Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells

Natural Bacterial and Fungal Peptides as a Promising Treatment to Defeat Lung Cancer Cells

Chemical synthesis and mechanism of a natural product from endolichenic fungus with a broad-spectrum anti microorganism activity

Phoma spp. an untapped treasure of cytotoxic compounds: current status and perspectives

Contact Info

Product

Resources

About