Exploration of plasticizer and plastic explosive detection and differentiation with serum albumin cross-reactive arrays

Ivy, Michelle Adams; Gallagher, Lauren; Ellington, Andrew D.; Anslyn, Eric V.

doi:10.1039/c2sc20083j

Cited by 30 publications

(23 citation statements)

References 23 publications

(35 reference statements)

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“…Alternatively, differential responses to ROS might be exploited to obtain “fingerprints” for the different species. Such a strategy is reminiscent of the pattern‐based recognition of peptides,27a,b terpenes,27c flavonoids27d, and plastic explosives27e based on UV/Vis absorption changes. Alkylated coumarins 3 a – d were prepared from 7‐hydroxycoumarin 1 (Scheme ).…”

Section: Resultsmentioning

confidence: 99%

A Versatile Long‐Wavelength‐Absorbing Scaffold for Eu‐Based Responsive Probes

Szíjjártó

Pershagen

Ilchenko

et al. 2013

Chemistry A European J

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Coumarin-sensitized, long-wavelength-absorbing luminescent Eu(III)-complexes have been synthesized and characterized. The lanthanide binding site consists of a cyclen-based chelating framework that is attached through a short linker to a 7-hydroxycoumarin, a 7-B(OH)(2)-coumarin, a 7-O-(4-pinacolatoboronbenzyl)-coumarin or a 7-O-(4-methoxybenzyl)-coumarin. The syntheses are straightforward, use readily available building blocks, and proceed through a small number of high-yielding steps. The sensitivity of coumarin photophysics to the 7-substituent enables modulation of the antenna-absorption properties, and thus the lanthanide excitation spectrum. Reactions of the boronate-based functionalities (cages) with H(2)O(2) yielded the corresponding 7-hydroxycoumarin species. The same species was produced with peroxynitrite in a ×10(6)-10(7)-fold faster reaction. Both reactions resulted in the emergence of a strong ≈407 nm excitation band, with concomitant decrease of the 366 nm band of the caged probe. In aqueous solution the methoxybenzyl caged Eu-complex was quenched by ONOO(-). We have shown that preliminary screening of simple coumarin-based antennae through UV/Vis absorption spectroscopy is possible as the changes in absorption profile translate with good fidelity to changes in Eu(III)-excitation profile in the fully elaborated complex. Taken together, our results show that the 7-hydroxycoumarin antenna is a viable scaffold for the construction of turn-on and ratiometric luminescent probes.

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Section: Resultsmentioning

confidence: 99%

A Versatile Long‐Wavelength‐Absorbing Scaffold for Eu‐Based Responsive Probes

Szíjjártó

Pershagen

Ilchenko

et al. 2013

Chemistry A European J

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“…The primary sequence of SAs differs between species, which thus exhibit differences in ligand binding (41). Previously, we have used arrays of SAs for the differentiation of other hydrophobic analytes including fatty acids (48), terpenes (49), and plasticizers (50). However, none of these previous studies involved differences between the analyte structures as subtle as glycerides do, nor had we challenged our methods to identify structural aspects of an unknown.…”

Section: Significancementioning

confidence: 99%

Differential sensing for the regio- and stereoselective identification and quantitation of glycerides

Diehl

Ivy

Rabidoux

et al. 2015

Proc. Natl. Acad. Sci. U.S.A.

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Glycerides are of interest to the areas of food science and medicine because they are the main component of fat. From a chemical sensing perspective, glycerides are challenging analytes because they are structurally similar to one another and lack diversity in terms of functional groups. Furthermore, because animal and plant fat consists of a number of stereo-and regioisomeric acylglycerols, their components remain challenging analytes for chromatographic and mass spectrometric determination, particularly the quantitation of species in mixtures. In this study, we demonstrated the use of an array of cross-reactive serum albumins and fluorescent indicators with chemometric analysis to differentiate a panel of mono-, di-, and triglycerides. Due to the difficulties in identifying the regio-and stereochemistry of the unsaturated glycerides, a sample pretreatment consisting of olefin cross-metathesis with an allyl fluorescein species was used before array analysis. Using this simple assay, we successfully discriminated 20 glycerides via principal component analysis and linear discriminant analysis (PCA and LDA, respectively), including stereo-and regioisomeric pairs. The resulting chemometric patterns were used as a training space for which the structural characteristics of unknown glycerides were identified. In addition, by using our array to perform a standard addition analysis on a mixture of triglycerides and using a method introduced herein, we demonstrated the ability to quantitate glyceride components in a mixture.array sensing | glyceride | chemometrics | serum albumin | differential sensing

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“…It was reported that the explosive power of 2,4,6‐trinitrophenol (TNP) is similar to a highly explosive compound TNT . Apart from its explosive nature, TNP is considered as a main toxic pollutant, which harshly affects soil and ground water and poses a significant health hazard because of its high solubility in water . Short‐term exposure to TNP causes eye and skin irritation, whereas long‐term exposure may cause damage to the kidneys and respiratory organs .…”

Section: Introductionmentioning

confidence: 99%

Multiple Emitting Amphiphilic Conjugated Polythiophenes‐Coated CdTe QDs for Picogram Detection of Trinitrophenol Explosive and Application Using Chitosan Film and Paper‐Based Sensor Coupled with Smartphone

et al. 2018

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Novel multiple emitting amphiphilic conjugated polythiophene‐coated CdTe quantum dots for picogram level determination of the 2,4,6‐trinitrophenol (TNP) explosive are developed. Four biocompatible sensors, cationic polythiophene nanohybrids (CPTQDs), nonionic polythiophene nanohybrids (NPTQDs), anionic polythiophene nanohybrids (APTQDs), and thiophene copolymer nanohybrids (TCPQDs), are designed using an in situ polymerization method, which shows highly enhanced fluorescence intensity and quantum yield (up to 78%). All sensors are investigated for nitroexplosive detection to provide a remarkable fluorescence quenching for TNP and the quenching efficiency reached 96% in the case of TCPQDs. The fluorescence of the sensors are quenched by TNP through inner filter effect, electrostatic, π−π, and hydrogen bonding interactions. Under optimal conditions, the detection limits of CPTQDs, NPTQDs, APTQDs, and TCPQDs are 2.56, 7.23, 4.12, and 0.56 × 10−9 m, respectively, within 60 s. More importantly, portable, cost effective, and simple to use paper strips and chitosan film are successfully applied to visually detect as little as 2.29 pg of TNP. The possibility of utilizing a smartphone with a color‐scanning APP in the determination of TNP is also established. Moreover, the practical application of the developed sensors for TNP detection in tap and river water samples is described with satisfactory recoveries of 98.02−107.50%.

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Exploration of plasticizer and plastic explosive detection and differentiation with serum albumin cross-reactive arrays

Cited by 30 publications

References 23 publications

A Versatile Long‐Wavelength‐Absorbing Scaffold for Eu‐Based Responsive Probes

A Versatile Long‐Wavelength‐Absorbing Scaffold for Eu‐Based Responsive Probes

Differential sensing for the regio- and stereoselective identification and quantitation of glycerides

Multiple Emitting Amphiphilic Conjugated Polythiophenes‐Coated CdTe QDs for Picogram Detection of Trinitrophenol Explosive and Application Using Chitosan Film and Paper‐Based Sensor Coupled with Smartphone

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