Exploration of mRNA nanoparticles based on DOTAP through optimization of the helper lipids
Xueni Ma,
Fanqi Wu,
Caihong Peng
et al.
Abstract:Lipid nanoparticles (LNPs) are one of the most efficient carriers for RNA packaging and delivery, and vaccines based on mRNA‐LNPs have received substantial attention since the outbreak of the COVID‐19 pandemic. LNPs based on 1,2‐dioleoyl‐3‐trimethylammonium propane (DOTAP) have been widely used in preclinical and clinical settings. We have previously developed a novel non‐viral gene delivery system called LNP3, which was composed of DOTAP, 1,2‐dioleoyl‐sn‐glycero‐3‐phosphoethanolamine (DOPE), and cholesterol. … Show more
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