Exploration of Iron and Copper Homeostasis in the Belgrade Rat Model of Iron Deficiency

Jiang, Lingli; Lu, Yan; Kim, Changae; Ranganathan, Perungavur N.; Collins, James F.

doi:10.1096/fasebj.25.1_supplement.238.7

Cited by 1 publication

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“…It presents in high concentrations and is closely related to the enzyme catalysis and electron transfer process. It exists in the human body as either Cu (I) or Cu (II) [2]. The shift between these two oxidation states shows their role in oxidation and reduction reactions in the phosphorylation pathway.…”

Section: Cu (I)/cu (Ii)mentioning

confidence: 99%

“…It participates in the function of cuproenzyme which is important in connective tissue formation, nerve transmission, iron homeostasis and angiogenesis. Copper is essentially involved in many proteins including ceruloplasmin, cytochrome c oxidase, dopamine β-hydroxylase and hephaestin [2]. Also, due to its essential role in participating in redox reactions, free copper could be toxic.…”

Section: Cu (I)/cu (Ii)mentioning

confidence: 99%

“…Excessive amount of iron in the human body causes cellular dysfunction and damage, hemochromatosis and bronze diabetes. Likewise, a insufficient amount of iron ions results in decreased intestinal absorption, disruption of hemoglobin transport of oxygen and mutations in the iron response elements of iron regulated mRNAs [2]. Here, the detection of both Fe (II) and Fe (III) will be given.…”

Section: Fe (Ii)/fe (Iii)mentioning

confidence: 99%

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Review of the detection of metal ions using fluorescent probes

2023

TNS

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Metal ions, essential for numerous physiological functions of the human body require accurate monitoring in order to gain precise knowledge of the health status of people. As fluorescent probes advances, the level of metal ions can be measured with high selectivity and sensitivity. Allowing the homeostasis of numerous metal ions to be maintained easily. Fluorescent probes are a hot area of research, providing a prospective tool for the detection of metal ions and to provide critical statistics in maintaining the homeostasis of the human body. This article introduces several fluorescent probes on the detection of both essential and toxic metal ions. It gives a review about the recent development in the detection of metal ions using fluorescent probes. This article explains the mechanism of recognition of each fluorescent probe and summarizes the results obtained from experiments. Outlining the advantages and shortcomings of each fluorescent probe. It includes novel fluorescent probes based on uncommon mechanisms.

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Section: Cu (I)/cu (Ii)mentioning

confidence: 99%

Section: Cu (I)/cu (Ii)mentioning

confidence: 99%

Section: Fe (Ii)/fe (Iii)mentioning

confidence: 99%

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