Exploration of inclusion complexes of neurotransmitters with β-cyclodextrin by physicochemical techniques

Roy, Debadrita; Saha, Subhadeep; Kundu, Mitali; Saha, Binoy Chandra; Barman, Siti

doi:10.1016/j.cplett.2016.05.031

Cited by 41 publications

(41 citation statements)

References 38 publications

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“…Due to ionic interactions there was significant increase in γ of the aqueous solution of vitamin. β-CD, in contrast, because of having hydrophobic outer surface and hydrophilic rims, hardly show any change in γ while dissolved in aqueous medium for a wide range of concentration [32]. In the present study γ of aqueous vitamin has been measured with increasing concentration of β-CD at 298.15 K. The vitamin showed progressively falling trend of γ with increasing concentration of β-CD, may be due to encapsulation of the vitamin molecule from the surface of the solution into the hydrophobic cavity of β-CD forming hostguest inclusion complex ( Figure 6) [33].…”

Section: Surface Tension Study Elucidates the Inclusion As Well As Stmentioning

confidence: 99%

“…Surface tension (γ) study gives important clue about the formation and the stoichiometry of the host-guest IC [30][31][32]. Due to ionic interactions there was significant increase in γ of the aqueous solution of vitamin.…”

Section: Surface Tension Study Elucidates the Inclusion As Well As Stmentioning

confidence: 99%

“…There is a linear relationship between lnK a and 1/T in the above equation, on the basis of which the thermodynamic parameters ΔH and ΔS for the formation of IC may be obtained [32,37,43].…”

Section: Ultraviolet Spectroscopy: Association Constants and Thermodymentioning

confidence: 99%

“…Conductivity (κ) measurement is an important tool to elucidate the inclusion phenomenon in solution phase [30,32]. It indicates the formation as well as the stoichiometry of the IC formed [37,38].…”

Section: Conductivity Study Demonstrates Inclusion Process and Its Stmentioning

confidence: 99%

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Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Saha¹,

Roy²

2017

Vitamin C

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Host-guest inclusion complex (IC) of vitamin C with β-cyclodextrin (β-CD) in aqueous medium has been explored by spectroscopic, physicochemical and calorimetric methods as stabilizer, carrier and regulatory releaser. Job plot has been drawn by UV-visible spectroscopy to confirm the 1:1 stoichiometry of the host-guest assembly. Stereo-chemical nature of the inclusion complex has been explained by two-dimensional (2D) NMR spectroscopy. Surface tension and conductivity studies further support the inclusion process. Association constants for the vitamin C-β-CD inclusion complex have been calculated by UV-visible spectroscopy using both Benesi-Hildebrand method and nonlinear programme, while the thermodynamic parameters have been estimated with the help of van't Hoff equation. Isothermal titration calorimetric study has been performed to determine the stoichiometry, association constant and thermodynamic parameters with high accuracy.

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Section: Surface Tension Study Elucidates the Inclusion As Well As Stmentioning

confidence: 99%

Section: Surface Tension Study Elucidates the Inclusion As Well As Stmentioning

confidence: 99%

Section: Ultraviolet Spectroscopy: Association Constants and Thermodymentioning

confidence: 99%

Section: Conductivity Study Demonstrates Inclusion Process and Its Stmentioning

confidence: 99%

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Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Saha¹,

Roy²

2017

Vitamin C

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“…[47,48] The use of β-CD on drug solubility, bioavailability, safety, stability, and as a carrier in drug formulation may be attained by the formation of inclusion complexes with drug molecules; in fact, the use of β-CD already has a long history in pharmacy. [49,50] β-CD consists of seven glucopyranose residues and is only moderately soluble in water because of intermolecular hydrogen bonding. Modified CDs with alkylated hydroxyl groups, such as randomly methylated-β-cyclodextrin (M-β-CD) break up this hydrogen bonding network and are considerably more water soluble.…”

Section: β-Cyclodextrin (β-Cd)mentioning

confidence: 99%

Untitled

Budhwar¹

2018

AJP

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Inclusion complexes have various applications in different fields of drug delivery and pharmaceutical industry due to their ability of complexation with guest molecules and enhancement of the physicochemical properties of guest molecules. Cyclodextrins and their derivatives have the ability to encapsulate the bioactive compounds into its cavity and protect these from the environmental conditions, improve the solubility, bioavailability, and other properties also. The aim of this review is to highlight the advantages of cyclodextrins in the enhancement of physicochemical properties of drugs (such as solubility, stability, bioavailability, permeability, and others), different methods for production and various characterization techniques used for evaluation of complexes. Applications of cyclodextrin complexes in pharmaceutical and other fields are also explained here with examples. Thus cyclodextrins, because of their continuing ability to find several novel applications in drug delivery, are expected to solve many problems accompanied with the delivery of different novel drugs through various delivery routes.

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A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency

Sofian

Benaouda

Wang

et al. 2020

Advanced Therapeutics

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Ion‐pairing a lifesaving drug such as theophylline with a targeting moiety could have a significant impact on medical emergencies such as status asthmaticus or COVID‐19 induced pneumomediastinum. However, to achieve rapid drug targeting in vivo the ion‐pair must be protected against breakdown before the entry into the target tissue. This study aims to investigate if inserting theophylline, when ion‐paired to the polyamine transporter substrate spermine, into a cyclodextrin (CD), to form a triplex, could direct the bronchodilator to the lungs selectively after intravenous administration. NMR demonstrates that upon the formation of the triplex spermine protruded from the CD cavity and this results in energy‐dependent uptake in A549 cells (1.8‐fold enhancement), which persists for more than 20 min. In vivo, the triplex produces a 2.4‐fold and 2.2‐fold increase in theophylline in the lungs 20 min after injection in rats and mice, respectively ( p < 0.05). The lung targeting is selective with no increase in uptake into the brain or the heart where the side‐effects of theophylline are treatment‐limiting. Selectively doubling the concentration of theophylline in the lungs could improve the benefit‐risk ratio of this narrow therapeutic index medicine, which continues to be important in critical care.

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Exploration of inclusion complexes of neurotransmitters with β-cyclodextrin by physicochemical techniques

Cited by 41 publications

References 38 publications

Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Encapsulation of Vitamin C into β‐Cyclodextrin for Advanced and Regulatory Release

Untitled

A Cyclodextrin‐Stabilized Spermine‐Tagged Drug Triplex that Targets Theophylline to the Lungs Selectively in Respiratory Emergency

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